The neural bases of proactive and reactive control processes in normal aging

[en] Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact. As proactive and reactive control abilities are associated with specific brain networks, this study investigated age-related effects on the neural substrates associated with each kind of control. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to groups of 20 young and 20 older healthy adults. Based on the theory of dual mechanisms of control, the Stroop task has been built to induce proactive or reactive control depending on task context. Results. Behavioral results (p < .05) indicated faster processing of interfering items in the mostly incongruent (MI) than the mostly congruent (MC) context in both young and older participants. fMRI results showed that reactive control is associated with increased activity in left frontal areas for older participants. For proactive control, decreased activity in the bilateral anterior cingulate cortex was associated with more activity in the right middle frontal gyrus in the older than the younger group. Conclusion. These observations support the hypothesis that aging affects the neural networks associated with reactive and proactive cognitive control differentially. These age-related changes are very similar to those observed in young adults with low dopamine availability, suggesting that a general mechanism (prefrontal dopamine availability) may modulate brain networks associated with various kinds of cognitive control.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Manard, Marine ; Université de Liège > Centre de recherches du cyclotron

François, Sarah ; Université de Liège > Département de Psychologie > Neuropsychologie

Phillips, Christophe ; Université de Liège > Centre de recherches du cyclotron

SALMON, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie

Collette, Fabienne ; Université de Liège > Département de Psychologie > Neuropsychologie

Language :

English

Title :

The neural bases of proactive and reactive control processes in normal aging

Publication date :

2017

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

320

Pages :

504-516

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Fondation Léon Fredericq
InterUniversity Attraction Pole (IUAP P7/11)

Available on ORBi :

since 16 November 2016

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