A P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expression in Airway Epithelial Cells.

Theatre, Emilie; Bours, Vincent; Oury, Cécile

doi:10.1165/rcmb.2008-0452OC

Article (Scientific journals)

A P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expression in Airway Epithelial Cells.

Theatre, Emilie; Bours, Vincent; Oury, Cécile

2009 • In American Journal of Respiratory Cell and Molecular Biology

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/20341

DOI
10.1165/rcmb.2008-0452OC

PubMed
19265173

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Keywords :

airway inflammation; purinergic receptors; NF-kappaB

Abstract :

[en] Extracellular ATP, acting at P2Y and P2X receptors, has recently been shown to contribute to airway inflammation. Using different epithelial cell models, this study shows that ATP promotes TNF-alpha-elicited IL-8 expression through P2X ion channel-triggered Ca(2+) entry, leading to CaMK-dependent IKK activation and binding of active p65 to IL-8 gene promoter.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Theatre, Emilie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine

Bours, Vincent ; Université de Liège - ULiège > Génétique

Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique générale et humaine

Language :

English

Title :

A P2X Ion Channel-triggered NF-{kappa}B Pathway Enhances TNF-{alpha}-induced IL-8 Expression in Airway Epithelial Cells.

Publication date :

2009

Journal title :

American Journal of Respiratory Cell and Molecular Biology

ISSN :

1044-1549

eISSN :

1535-4989

Publisher :

American Thoracic Society, New York, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 August 2009

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