Article (Scientific journals)
Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA
Gillet, Nicolas; Willems, Luc
2016In Retrovirology, p. 13:75
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Keywords :
:Breast cancer; Bovine leukemia virus; BLV
Abstract :
[en] Controversy exists regarding the association of bovine leukemia virus (BLV) and breast cancer. PCR-based experimental evidence indicates that BLV DNA is present in breast tissue and that as many as 37% of cancer cases may be attributable to viral exposure. Since this association might have major consequences for human health, we evaluated 51 whole genomes of breast cancer samples for the presence of BLV DNA. Among 32 billion sequencing reads retrieved from the NCBI database of genotype and phenotype, none mapped on different strains of the BLV genome. Controls for sequence divergence and proviral loads further validated the approach. This unbiased analysis thus excludes a clonal insertion of BLV in breast tumor cells and strongly argues against an association between BLV and breast cancer.
Disciplines :
Oncology
Author, co-author :
Gillet, Nicolas ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Willems, Luc  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Language :
English
Title :
Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA
Publication date :
2016
Journal title :
Retrovirology
eISSN :
1742-4690
Publisher :
BioMed Central, London, United Kingdom
Pages :
13:75
Peer reviewed :
Peer Reviewed verified by ORBi
Tags :
CÉCI : Consortium des Équipements de Calcul Intensif
Name of the research project :
IAP - Interuniversity Attraction Poles Program “Virus-host interplay at the early phases of infection” BELVIR
AgricultureIsLife
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
BELSPO - Politique scientifique fédérale [BE]
Belgian Foundation Against Cancer [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
ULg FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
CÉCI - Consortium des Équipements de Calcul Intensif [BE]
Fonds Léon Fredericq [BE]
Funding text :
The COFUND program, the ERA-IB Astinprod and the “Plan Cancer” of the “Service Public Fédéral”
Available on ORBi :
since 10 November 2016

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