Reference : Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/203205
Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice
English
Gijs, Marlies []
Becker, Guillaume mailto [Université de Liège > > Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège > Département de chimie (sciences) > Département de chimie (sciences) >]
Bahri, Mohamed Ali mailto [Université de Liège > Centre de Recherches du Cyclotron > Centre de Recherches du Cyclotron > > >]
Aerts, An []
Impens, Nathalie []
Baatout, Sarah []
Luxen, André mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
11-Aug-2016
Journal of Nuclear Medicine and Radiation Therapy
7
5
Yes
International
[en] Aptamers ; HER2 receptor ; 68Ga ; PET imaging ; bio-distribution ; tumor-targeting
[en] Background: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential of these HER2 aptamers.
Methods: Both HER2 aptamers were radiolabelled with 68Ga, injected in mice bearing a HER2-positive and HER2-negative tumour and evaluated by PET/MRI.
Results: Ex vivo bio distribution analysis revealed high uptake in the blood, tissues and organs, except the brain. Interestingly, this high uptake was explained by the slow blood clearance due to non-specific aptamer binding to blood proteins. We observed accumulation of radioactivity in both tumours in time. Although higher uptake in the HER2-positive tumour compared to the HER2-negative tumour was observed, this was accompanied with more necrosis in the HER2-negative tumour, which was observed by 18FDG PET/CT.
Conclusion: This work presents a first step towards the development of 68Ga-labelled aptamers for molecular cancer imaging.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/203205
10.4172/2155-9619.1000300
http://www.omicsonline.org/open-access/biodistribution-of-novel-68garadiolabelled-her2-aptamers-in-mice-2155-9619-1000300.php?aid=79211

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