Poster (Scientific congresses and symposiums)
Contribution of Cross-linking and Ion-mobility for the study of protein and complex structures
Baumans, France; Grifnée, Elodie; Hage, Christoph et al.
2016International School of Biophysics
 

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Keywords :
Mass spectrometry; Cross-linking; Protein structure
Abstract :
[en] The tridimensional structures of proteins and the mapping of protein-protein interactions are precious sources of information for the understanding of their function. Different techniques such as X-ray cristallography or nuclear magnetic resonance are usually used to achieve this goal. In the field of mass spectrometry, several tools were also developped. The one presented here is the chemical cross-linking in which two reactive residue side chains, spatially close, are linked thanks to a bifunctional chemical, called crosslinker. Ion-mobility coupled to mass spectrometry has also been investigated for the study of cross-linked products. The first results tend to show that cross-linkers allow to fix the shape of the protein in solution, leaving it intact when analysed in the gas phase.
Research center :
Laboratoire de Spectrométrie de Masse
Disciplines :
Chemistry
Author, co-author :
Baumans, France ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Other collaborator :
Grifnée, Elodie ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Hage, Christoph;  Martin-Luther University of Halle-Wittenberg > Departement of Pharmaceutical Chemistry and Bioanalytics > Institute of Pharmacy
Quinton, Loïc  ;  Université de Liège > Département de chimie (sciences) > Chimie biologique
Sinz, Andrea;  Martin-Luther University of Halle-Wittenberg > Department of Pharmaceutical Chemistry and Bioanalytics > Institute of Pharmacy
De Pauw, Edwin  ;  Université de Liège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.)
Language :
English
Title :
Contribution of Cross-linking and Ion-mobility for the study of protein and complex structures
Alternative titles :
[fr] Apport du cross-linking et de la mobilité ionique pour l'étude de la structure de protéines et de leurs complexes
Publication date :
05 September 2016
Number of pages :
A0
Event name :
International School of Biophysics
Event organizer :
The Croatian Biophysical Society
Event place :
Split, Rogoznica, Zadar, Sali, Croatia
Event date :
1st september 2016 to 10th steptember 2016
Audience :
International
Available on ORBi :
since 07 October 2016

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