Relating pessimistic memory predictions to Alzheimer’s disease brain structure

[en] Patients with Alzheimer’s disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients. AD patients and healthy older participants provided predictive judgements on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between grey matter volume (GMV) in T1 images and behavioural scores were examined with multivariate (PLS) and univariate (GLM) analyses in AD patients. AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction (Prediction_low_hits) in episodic memory. PLS revealed that behavioural pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex, but also right ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC. Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one’s own memory performance are primarily related to decrease GMV in VLPFC in AD patients.

Disciplines :

Neurosciences & behavior

Author, co-author :

Genon, Sarah ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Simon, Jessica ; Université de Liège > Département de Psychologie > Psychologie quantitative

Bahri, Mohamed Ali ; Université de Liège > Centre de Recherches du Cyclotron > Centre de Recherches du Cyclotron

Collette, Fabienne ; Université de Liège > Département de Psychologie > Neuropsychologie

Souchay, Céline

Jaspar, Mathieu ; Université de Liège > Département de Psychologie > Ergonomie et intervention au travail

Bastin, Christine ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

SALMON, Eric ; Centre Hospitalier Universitaire de Liège - CHU > Service de neurologie

Language :

English

Title :

Relating pessimistic memory predictions to Alzheimer’s disease brain structure

Publication date :

December 2016

Journal title :

Cortex: A Journal Devoted to the Study of the Nervous System and Behavior

ISSN :

0010-9452

eISSN :

1973-8102

Publisher :

Masson, Milano, Italy

Volume :

Pages :

151-164

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 30 September 2016

Statistics

Number of views

224 (22 by ULiège)

Number of downloads

356 (6 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Amunts, K., Kedo, O., Kindler, M., Pieperhoff, P., Mohlberg, H., Shah, N., et al. Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: Intersubject variability and probability maps. Anatomy and Embryology 210:5–6 (2005), 343–352.
Amunts, K., Schleicher, A., Bürgel, U., Mohlberg, H., Uylings, H., Zilles, K., Broca's region revisited: Cytoarchitecture and intersubject variability. Journal of Comparative Neurology 412:2 (1999), 319–341.
Backman, L., Lipinska, B., Monitoring of general knowledge: Evidence for preservation in early Alzheimer's disease. Neuropsychologia 31:4 (1993), 335–345.
Bludau, S., Eickhoff, S.B., Mohlberg, H., Caspers, S., Laird, A.R., Fox, P.T., et al. Cytoarchitecture, probability maps and functions of the human frontal pole. NeuroImage 93:Pt 2 (2014), 260–275.
Buckner, R.L., Snyder, A.Z., Shannon, B.J., LaRossa, G., Sachs, R., Fotenos, A.F., et al. Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory. The Journal of Neuroscience 25:34 (2005), 7709–7717.
Burton, A.M., White, D., McNeill, A., The Glasgow face matching test. Behavior Research Methods 42:1 (2010), 286–291.
Cabeza, R., Anderson, N.D., Locantore, J.K., McIntosh, A.R., Aging gracefully: Compensatory brain activity in high-performing older adults. NeuroImage 17:3 (2002), 1394–1402.
Cabeza, R., Locantore, J.K., Anderson, N.D., Lateralization of prefrontal activity during episodic memory retrieval: Evidence for the production-monitoring hypothesis. Journal of Cognitive Neuroscience 15:2 (2003), 249–259.
Chua, E.F., Schacter, D.L., Sperling, R.A., Neural correlates of metamemory: A comparison of feeling-of-knowing and retrospective confidence judgments. Journal of Cognitive Neuroscience 21:9 (2009), 1751–1765.
Clare, L., Whitaker, C.J., Nelis, S.M., Appraisal of memory functioning and memory performance in healthy ageing and early-stage Alzheimer's disease. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition 17:4 (2010), 462–491.
Dalla Barba, G., Recognition memory and recollective experience in Alzheimer's disease. Memory 5:6 (1997), 657–672.
Dalla Barba, G., Parlato, V., Jobert, A., Samson, Y., Pappata, S., Cortical networks implicated in semantic and episodic memory: Common or unique?. Cortex 34:4 (1998), 547–561.
Deichmann, R., Schwarzbauer, C., Turner, R., Optimisation of the 3D MDEFT sequence for anatomical brain imaging: Technical implications at 1.5 and 3 T. NeuroImage 21 (2004), 757–767.
Diedrichsen, J., Balsters, J.H., Flavell, J., Cussans, E., Ramnani, N., A probabilistic MR atlas of the human cerebellum. NeuroImage 46:1 (2009), 39–46.
Dodson, C.S., Spaniol, M., O'Connor, M.K., Deason, R.G., Ally, B.A., Budson, A.E., Alzheimer's disease and memory-monitoring impairment: Alzheimer's patients show a monitoring deficit that is greater than their accuracy deficit. Neuropsychologia 49:9 (2011), 2609–2618.
Duke, L.M., Seltzer, B., Seltzer, J.E., Vasterling, J.J., Cognitive components of deficit awareness in Alzheimer's disease. Neuropsychology, 16(3), 2002, 359.
Eakin, D.K., Hertzog, C., Harris, W., Age invariance in semantic and episodic metamemory: Both younger and older adults provide accurate feeling-of-knowing for names of faces. Aging, Neuropsychology, and Cognition 21:1 (2014), 27–51.
Gallo, D.A., Cramer, S.J., Wong, J.T., Bennett, D.A., Alzheimer's disease can spare local metacognition despite global anosognosia: Revisiting the confidence-accuracy relationship in episodic memory. Neuropsychologia 50:9 (2012), 2356–2364.
Genon, S., Bahri, M.A., Collette, F., Angel, L., d'Argembeau, A., Clarys, D., et al. Cognitive and neuroimaging evidence of impaired interaction between self and memory in Alzheimer's disease. Cortex 51 (2014), 11–24.
Genon, S., Collette, F., Feyers, D., Phillips, C., Salmon, E., Bastin, C., Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study. Cortex 49:6 (2013), 1566–1584.
Good, C.D., Johnsrude, I.S., Ashburner, J., Henson, R.N.A., Friston, K.J., Frackowiak, R.S.J., A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:1 (2001), 21–36.
Kanai, R., Rees, G., The structural basis of inter-individual differences in human behaviour and cognition. Nature Reviews Neuroscience 12:4 (2011), 231–242.
Kensinger, E.A., Schacter, D.L., Retrieving accurate and distorted memories: Neuroimaging evidence for effects of emotion. NeuroImage 27:1 (2005), 167–177.
Kikyo, H., Ohki, K., Miyashita, Y., Neural correlates for feeling-of-knowing: An fMRI parametric analysis. Neuron 36:1 (2002), 177–186.
Kinzer, A., Suhr, J.A., Dementia worry and its relationship to dementia exposure, psychological factors, and subjective memory concerns. Applied Neuropsychology. Adult 23:3 (2016), 196–204.
Koriat, A., How do we know that we know? The accessibility model of the feeling of knowing. Psychological Review 100 (1993), 609–639.
Koriat, A., Levy-Sadot, R., The combined contributions of the cue-familiarity and accessibility heuristics to feelings of knowing. Journal of Experimental Psychology. Learning, Memory, and Cognition 27:1 (2001), 34–53.
Kroger, J.K., Sabb, F.W., Fales, C.L., Bookheimer, S.Y., Cohen, M.S., Holyoak, K.J., Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: A parametric study of relational complexity. Cerebral Cortex 12:5 (2002), 477–485.
Labudda, K., Woermann, F.G., Mertens, M., Pohlmann-Eden, B., Markowitsch, H.J., Brand, M., Neural correlates of decision making with explicit information about probabilities and incentives in elderly healthy subjects. Experimental Brain Research 187:4 (2008), 641–650.
Leech, R., Sharp, D.J., The role of the posterior cingulate cortex in cognition and disease. Brain 137:1 (2014), 12–32.
Lipinska, B., Backman, L., Feeling-of-knowing in fact retrieval: Further evidence for preservation in early Alzheimer's disease. Journal of the International Neuropsychological Society: JINS 2:4 (1996), 350–358.
Maril, A., Simons, J.S., Mitchell, J.P., Schwartz, B.L., Schacter, D.L., Feeling-of-knowing in episodic memory: An event-related fMRI study. NeuroImage 18:4 (2003), 827–836.
Mattis, S., Dementia rating scale. 1973, NFER-Nelson, Windsor, England.
McIntosh, A.R., Lobaugh, N.J., Partial least squares analysis of neuroimaging data: Applications and advances. NeuroImage 23:Suppl. 1 (2004), S250–S263.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34 (1984), 939–944.
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R., Kawas, C.H., et al. The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia 7:3 (2011), 263–269.
Mimura, M., Yano, M., Memory impairment and awareness of memory deficits in early-stage Alzheimer's disease. Reviews in the Neurosciences 17:1–2 (2006), 253–266.
Mitchell, K.J., Johnson, M.K., Source monitoring 15 years later: What have we learned from fMRI about the neural mechanisms of source memory?. Psychological Bulletin, 135(4), 2009, 638.
Mograbi, D.C., Ferri, C.P., Sosa, A.L., Stewart, R., Laks, J., Brown, R., et al. Unawareness of memory impairment in dementia: A population-based study. International Psychogeriatrics/IPA 24:6 (2012), 931–939.
Moulin, C.J.A., James, N., Perfect, T.J., Jones, R.W., Knowing what you cannot recognise: Further evidence for intact metacognition in Alzheimer's disease. Aging, Neuropsychology, and Cognition 10:1 (2003), 74–82.
Nee, D.E., Jonides, J., Common and distinct neural correlates of perceptual and memorial selection. NeuroImage 45:3 (2009), 963–975.
Nelson, T.O., Narens, L., Metamemory: A theoretical framework and some new findings. Bower, G.H., (eds.) The psychology of learning and motivation, 1990, Academic Press, San Diego, 125–173.
Pannu, J.K., Kaszniak, A.W., Metamemory experiments in neurological populations: A review. Neuropsychology Review 15:3 (2005), 105–130.
Paynter, C.A., Reder, L.M., Kieffaber, P.D., Knowing we know before we know: ERP correlates of initial feeling-of-knowing. Neuropsychologia 47:3 (2009), 796–803.
Perrotin, A., Belleville, S., Isingrini, M., Metamemory monitoring in mild cognitive impairment: Evidence of a less accurate episodic feeling-of-knowing. Neuropsychologia 45 (2007), 2811–2826.
Perrotin, A., Desgranges, B., Landeau, B., Mezenge, F., La Joie, R., Egret, S., et al. Anosognosia in Alzheimer disease: Disconnection between memory and self-related brain networks. Annals of Neurology 78:3 (2015), 477–486.
Schmitter-Edgecombe, M., Seelye, A.M., Predictions of verbal episodic memory in persons with Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology 33:2 (2011), 218–225.
Schnyer, D.M., Nicholls, L., Verfaellie, M., The role of VMPC in metamemorial judgments of content retrievability. Journal of Cognitive Neuroscience 17:5 (2005), 832–846.
Smith, S.M., Nichols, T.E., Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inference. NeuroImage 44:1 (2009), 83–98.
Souchay, C., Isingrini, M., Gil, M., Alzheimer's disease and feeling-of-knowing in episodic memory. Neuropsychologia 40 (2002), 2386–2396.
Souchay, C., Isingrini, M., Gil, R., Metamemory monitoring and Parkinson's disease. Journal of Clinical and Experimental Neuropsychology 28:4 (2006), 618–630.
Souchay, C., Moulin, C.J., Memory and consciousness in Alzheimer's disease. Current Alzheimer Research 6:3 (2009), 186–195.
Stewart, G., McGeown, W.J., Shanks, M.F., Venneri, A., Anosognosia for memory impairment in Alzheimer's disease. Acta Neuropsychiatrica 22:4 (2010), 180–187.
Suhr, J.A., Kinkela, J.H., Perceived threat of Alzheimer disease (AD): The role of personal experience with AD. Alzheimer Disease and Associated Disorders 21:3 (2007), 225–231.
Thomas, A.K., Bulevich, J.B., Dubois, S.J., Context affects feeling-of-knowing accuracy in younger and older adults. Journal of Experimental Psychology: Learning, Memory, and Cognition, 37(1), 2011, 96.
Walsh, N.D., Dalgleish, T., Lombardo, M.V., Dunn, V.J., Van Harmelen, A.-L., Ban, M., et al. General and specific effects of early-life psychosocial adversities on adolescent grey matter volume. NeuroImage: Clinical 4 (2014), 308–318.
Wegelin, J.A., A survey 0fPartia1 least squares (PLS) methods, with emphasis on the two-block case. 2000.
Ziegler, G., Dahnke, R., Winkler, A.D., Gaser, C., Partial least squares correlation of multivariate cognitive abilities and local brain structure in children and adolescents. NeuroImage 82 (2013), 284–294.