Reference : On the GMP production of [18]FUCB-H : Imaging neurotransmission
Dissertations and theses : Doctoral thesis
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/201903
On the GMP production of [18]FUCB-H : Imaging neurotransmission
English
Warnier, Corentin mailto [Université de Liège > > Centre de recherches du cyclotron >]
26-Sep-2016
Université de Liège, ​Liège, ​​Belgique
Docteur en Sciences
189
Luxen, André mailto
Damblon, Christian mailto
Lemaire, Christian mailto
Gouverneur, Véronique mailto
Valade, Anne mailto
Monbaliu, Jean-Christophe mailto
[en] fluorine-18 ; UCB-H ; PET ; iodonium ; 18F
[en] We herein describe the straightforward synthesis of a stable pyridyl(aryl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radi-osynthesis of [18F]UCB-H, a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A). Over the course of one year, 40 automated productions provided 34±2% of injectable [18F]UCB-H from up to 7.7 Ci of [18F]fluoride in 50 minutes (uncorrected radiochemical yield. Specific Activity = 22±5 Ci/µmol). The successful implementation of our synthetic strategy within routine, high-activity and cGMP productions attests to its practicality and reliability for the production of large doses of [18F]UCB-H. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts in the cGMP 18F-PET tracer manufacturing industry and their ability to fulfill practical and regulatory requirements in that field.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Region Wallonne
Researchers ; Professionals
http://hdl.handle.net/2268/201903

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