Reference : Considerations in parathyroid hormone testing.
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/201791
Considerations in parathyroid hormone testing.
English
Cavalier, Etienne mailto [Université de Liège > Département de pharmacie > Chimie médicale >]
Plebani, Mario []
DELANAYE, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de néphrologie >]
Souberbielle, Jean-Claude [> >]
Nov-2015
Clinical Chemistry & Laboratory Medicine
53
12
1913-9
Yes (verified by ORBi)
International
1434-6621
1437-4331
Germany
[en] Clinical Laboratory Techniques ; Humans ; Parathyroid Hormone/analysis/metabolism
[en] Parathyroid hormone (PTH) is a major player in phosphocalcic metabolism and its measurement is very important for the correct diagnosis and treatment of several diseases. PTH determination represents the paradigm of quality in laboratory medicine as many variables in the pre-, intra-, and post-analytical phases strongly affect the value of the clinical information. Analytical determination of PTH has been rendered difficult by the presence, in the circulation, of truncated fragments that can cross-react with the antibodies used for its determination. In addition, pre-analytical phase is complicated by the lack of stability of the peptide and the best sample to use for its determination remains controversial, as well as sample handling and storage. PTH secretion is also affected by circadian and seasonal rhythms and by physical exercise. Finally, from the post-analytical perspective, establishment of reliable reference ranges requires further efforts as the selection criteria for reference subjects should take into consideration new variables such as gender, race and vitamin D levels. Finally, clinical guidelines have recently revised and improved the criteria for a correct interpretation of PTH values.
http://hdl.handle.net/2268/201791
10.1515/cclm-2015-0314
http://www.degruyter.com/doi/10.1515/cclm-2015-0314

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