Reference : Osteoporosis and sarcopenia: two diseases or one?
Scientific journals : Article
Human health sciences : Public health, health care sciences & services
Human health sciences : Rheumatology
http://hdl.handle.net/2268/201508
Osteoporosis and sarcopenia: two diseases or one?
English
Reginster, Jean-Yves mailto [Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Beaudart, Charlotte mailto [Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Buckinx, Fanny mailto [Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Bruyère, Olivier mailto [Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Jan-2016
Current Opinion in Clinical Nutrition and Metabolic Care
Lippincott Williams & Wilkins
19
1
31-6
Yes (verified by ORBi)
International
1363-1950
1473-6519
London
United Kingdom
[en] bone ; muscle ; myostatin ; osteoporosis ; sarcopenia
[en] Purpose of review
This article reviews recently published evidence for common pathways explaining bone and muscle wasting
in normal ageing and pathological conditions.
Recent findings
Numerous studies support the concept of a bone–muscle unit, where constant cross-talking between the two
tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and
osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells.
Summary
New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed
by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the
communication between the two tissues.
http://hdl.handle.net/2268/201508
10.1097/MCO.0000000000000230

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