Article (Scientific journals)
Osteoporosis and sarcopenia: two diseases or one?
Reginster, Jean-Yves; Beaudart, Charlotte; Buckinx, Fanny et al.
2016In Current Opinion in Clinical Nutrition and Metabolic Care, 19 (1), p. 31-6
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Keywords :
bone; muscle; myostatin; osteoporosis; sarcopenia
Abstract :
[en] Purpose of review This article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions. Recent findings Numerous studies support the concept of a bone–muscle unit, where constant cross-talking between the two tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells. Summary New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the communication between the two tissues.
Disciplines :
Rheumatology
Public health, health care sciences & services
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Beaudart, Charlotte ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Buckinx, Fanny  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Bruyère, Olivier  ;  Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Osteoporosis and sarcopenia: two diseases or one?
Publication date :
January 2016
Journal title :
Current Opinion in Clinical Nutrition and Metabolic Care
ISSN :
1363-1950
eISSN :
1473-6519
Publisher :
Lippincott Williams & Wilkins, London, United Kingdom
Volume :
19
Issue :
1
Pages :
31-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 September 2016

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