Structural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide

[en] A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and antihypertensive properties of this polysaccharide. The CNSP consisted mainly of sulfate (23.17%), total sugars (54.90%), galactose (44.89%), mannose (17.30%), arabinose (12.05%), xylose (9.18%), maltose (1.07%) and uronic acid (11.03%) with low water activity (0.49). CNSP had an XRD pattern that was typical for a semi-crystalline polymer with homogeneous structure. It also displayed an important anti-hypertensive activity (IC50 = 0.43 mg ml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL). Overall, the results indicate that CNSP have attractive chemical, functional and biological properties, with a preliminary structural may have a backbone of branched 6-O-sulfated (1 → 4) galactosidic linkages, which can be considered in the future as alternative additive in various foods, cosmetic and pharmaceutical preparations.

Disciplines :

Biotechnology

Author, co-author :

Ben Abdallah Kolsi, Rihab

Fakhfakh, Jawhar

Krichen, Fatma

Jribi, Imed

Chiarore, Antonia

Patti, Francesco Paolo

Blecker, Christophe ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Science des alim. et formul.

Allouche, Noureddine

Belghith, Hafedh

Belghith, Karima

Language :

English

Title :

Structural characterization and functional properties of antihypertensive Cymodocea nodosa sulfated polysaccharide

Publication date :

2016

Journal title :

Carbohydrate Polymers

ISSN :

0144-8617

eISSN :

1879-1344

Publisher :

Elsevier Science

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 September 2016

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