[en] The optimal method to prepare endometrium before frozen embryo transfer (FET) is not yet
established. We retrospectively studied 4496 FET and detailed pregnancy and miscarriage rates
in three groups of patients according to the endometrium preparation they have followed
before their successive FET: clomifene citrate (CC, group 1), artificial cycle (AC, group 2) or
switch between CC and AC (group 3). The overall pregnancy rates per transfer were 24.3, 20.8
and 17.3% while the miscarriage rates reached 23.2, 29.8 and 42.5%, respectively. Group 1
experienced the highest ongoing pregnancy rate (18.6%), the lowest being observed in group 3
(10.0%, p50.001). Here we propose several alternatives to improve our AC protocol (group 2)
that seemed less effective than CC (group 1) and we consider the use of a gonadotrophinstimulated
treatment for patients with the lowest reproductive outcomes (group 3).
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
JOUAN, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR) - CPMA
EMONARD, Violaine ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
RUGGERI, Philippe ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR) - CPMA
DEBELLE, Laurent; Université de Reims Champagne Ardenne > UMR CNRS 7369 MEDyC > Lab. Signalisation et Récepteurs Matriciels - SIRMa
HINCOURT, Nadine; Centre Hospitalier Régional de la Citadelle (Liège) - CHR CITADELLE > Service de Gynécologie-Obstétrique (CHR)
LORQUET, Sophie; Centre Hospitalier Universitaire de Liège - CHU > Service de Gynécologie-Obstétrique (CHR)
DECHENNE, Valérie ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
GINER LLORET, Caroline ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
DUBOIS, Michel ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
PERRIER d'HAUTERIVE, Sophie ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR) - CPMA
NISOLLE, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > Service de gynécologie-obstétrique (CHR)
Language :
English
Title :
Pregnancy outcome following frozen embryo transfer after artificial cycle or treatment by clomiphene citrate.
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