Reference : The Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients Is Not Influ...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/200922
The Uptake of 18F-FDG by Renal Allograft in Kidney Transplant Recipients Is Not Influenced by Renal Function.
English
Jadoul, Alexandre mailto [> >]
LOVINFOSSE, Pierre mailto [> >]
Weekers, Laurent mailto [> >]
DELANAYE, Pierre mailto [Université de Liège > Département des sciences cliniques > Néphrologie >]
Krzesinski, Jean-Marie mailto [Université de Liège > Département des sciences cliniques > Néphrologie >]
Hustinx, Roland mailto [Université de Liège > Département des sciences cliniques > Médecine nucléaire >]
Jouret, François mailto [Université de Liège > Département des sciences cliniques > Néphrologie >]
2016
Clinical Nuclear Medicine
41
9
683-7
Yes (verified by ORBi)
International
0363-9762
1536-0229
United States
[en] 18F-FDG PET/CT ; kidney transplantation ; 18F-FDG uptake ; eGFR ; CKD-EPI equation ; chronic kidney disease (CKD)
[en] PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence of kidney function on F-FDG uptake by renal grafts remains unknown. PATIENTS AND METHODS: We retrospectively identified all KTRs who underwent at least one F-FDG PET/CT. Kidney transplant recipients with documented pyelonephritis or AR were excluded. Estimated glomerular filtration rate (eGFR) was assessed using chronic kidney disease (CKD)-EPI equation. Mean standardized uptake values (SUVmean) of renal graft cortex and aorta were measured in 4 and 1 volumes of interest, respectively. Spearman rank correlation coefficient (rho) and analysis of variance (ANOVA) were performed. RESULTS: Eighty-two KTRs underwent F-FDG PET/CT for tumor staging (n = 46), suspected infection (n = 11), or fever of unknown origin (n = 25). Mean eGFR was 50 +/- 19 mL/min per 1.73 m, including CKD stage 1 (n = 3), stage 2 (n = 21), stage 3a (n = 20), stage 3b (n = 29), and stage 4 (n = 9). Mean kidney and aorta SUVmean were 1.8 +/- 0.2 and 1.7 +/- 0.3, respectively. No significant correlation was observed between eGFR and kidney SUVmean (rho, 0.119; P, 0.28) or aorta SUVmean (rho, -0.144; P, 0.20). ANOVA showed no difference of kidney (P, 0.62) and aorta (P, 0.85) SUVmean between CKD groups. Mean coefficient of variation (on the basis of kidney SUVmean of >3 consecutive F-FDG PET/CT in 15 patients with no significant change of eGFR) reached 13.1%. CONCLUSIONS: The uptake of F-FDG by renal allografts within an hour postinjection is not significantly impacted by CKD.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/200922
10.1097/RLU.0000000000001298

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