Discrepancies between the Cockcroft–Gault and Chronic Kidney Disease Epidemiology (CKD-EPI) Equations: Implications for Refining Drug Dosage Adjustment Strategies
DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Guerber, Fabrice
SCHEEN, André ; Centre Hospitalier Universitaire de Liège - CHU > Service de diabétologie, nutrition, maladies métaboliques
Ellam, Timothy
BOUQUEGNEAU, Antoine ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Guergour, Dorra
Mariat, Christophe
Pottel, Hans
Language :
English
Title :
Discrepancies between the Cockcroft–Gault and Chronic Kidney Disease Epidemiology (CKD-EPI) Equations: Implications for Refining Drug Dosage Adjustment Strategies
Dreisbach AW, Flessner MF. Drug metabolism and chronic kidney disease. In: Kimmel PL, Rosenberg, MK, editors. Chronic renal disease. Academic Press; 2014. p. 674–81.
Verbeeck RK, Musuamba FT. Pharmacokinetics and dosage adjustment in patients with renal dysfunction. Eur J Clin Pharmacol. 2009;65:757–73.
Aymanns C, Keller F, Maus S, Hartmann B, Czock D. Review on pharmacokinetics and pharmacodynamics and the aging kidney. Clin J Am Soc Nephrol. 2010;5:314–27.
Elinder CG, Barany P, Heimburger O. The use of estimated glomerular filtration rate for dose adjustment of medications in the elderly. Drugs Aging. 2014;31:493–9.
EMA. 2014. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2014/02/WC500162133.pdf. Accessed 8 July 2016.
FDA. 2010. http://www.fda.gov/downloads/Drugs/Guidances/UCM204959.pdf. Accessed 8 July 2016.
Stevens LA, Nolin TD, Richardson MM, Feldman HI, Lewis JB, Rodby R, et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis. 2009;54:33–42.
Park EJ, Wu K, Mi Z, Dong T, Lawrence JP, Ko CW, et al. A systematic comparison of Cockcroft-Gault and modification of diet in renal disease equations for classification of kidney dysfunction and dosage adjustment. Ann Pharmacother. 2012;46:1174–87.
Bouquegneau A, Vidal-Petiot E, Moranne O, Mariat C, Boffa JJ, Vrtovsnik F, et al. Creatinine-based equations for the adjustment of drug dosage in an obese population. Br J Clin Pharmacol. 2016;81:349–61.
Melloni C, Peterson ED, Chen AY, Szczech LA, Newby LK, Harrington RA, et al. Cockcroft-Gault versus modification of diet in renal disease: importance of glomerular filtration rate formula for classification of chronic kidney disease in patients with non-ST-segment elevation acute coronary syndromes. J Am Coll Cardiol. 2008;51:991–6.
Corsonello A, Pedone C, Lattanzio F, Onder G, Inc A. Association between glomerular filtration rate and adverse drug reactions in elderly hospitalized patients: the role of the estimating equation. Drugs Aging. 2011;28:379–90.
Delanaye P, Mariat C. The applicability of eGFR equations to different populations. Nat Rev Nephrol. 2013;9:513–22.
Wargo KA, Eiland EH III, Hamm W, English TM, Phillippe HM. Comparison of the modification of diet in renal disease and Cockcroft-Gault equations for antimicrobial dosage adjustments. Ann Pharmacother. 2006;40:1248–53.
Golik MV, Lawrence KR. Comparison of dosing recommendations for antimicrobial drugs based on two methods for assessing kidney function: Cockcroft-Gault and modification of diet in renal disease. Pharmacotherapy. 2008;28:1125–32.
Hermsen ED, Maiefski M, Florescu MC, Qiu F, Rupp ME. Comparison of the modification of diet in renal disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacotherapy. 2009;29:649–55.
Okparavero AA, Tighiouart H, Krishnasami Z, Wyatt CM, Graham H, Hellinger J, et al. Use of glomerular filtration rate estimating equations for drug dosing in HIV-positive patients. Antivir Ther. 2013;18:793–802.
Gouin-Thibault I, Pautas E, Mahe I, Descarpentries C, Nivet-Antoine V, Golmard JL, et al. Is Modification of Diet in Renal Disease formula similar to Cockcroft-Gault formula to assess renal function in elderly hospitalized patients treated with low-molecular-weight heparin? J Gerontol A Biol Sci Med Sci. 2007;62:1300–5.
Gill J, Malyuk R, Djurdjev O, Levin A. Use of GFR equations to adjust drug doses in an elderly multi-ethnic group: a cautionary tale. Nephrol Dial Transplant. 2007;22:2894–9.
Healy MF, Speroni KG, Eugenio KR, Murphy PM. Adjusting eptifibatide doses for renal impairment: a model of dosing agreement among various methods of estimating creatinine clearance. Ann Pharmacother. 2012;46:477–83.
Maccallum PK, Mathur R, Hull S a, Saja K, Green L, Morris JK, et al. Patient safety and estimation of renal function in patients prescribed new oral anticoagulants for stroke prevention in atrial fibrillation: a cross-sectional study. BMJ Open 2013;3:e003343.
Helldén A, Odar-Cederlöf I, Nilsson G, Sjöviker S, Söderström A, Von Euler M, et al. Renal function estimations and dose recommendations for dabigatran, gabapentin and valaciclovir: a data simulation study focused on the elderly. BMJ Open. 2013;3:e002686.
Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, et al. Efficacy and safety of dabigatran compared with warfarin in relation to baseline renal function in patients with atrial fibrillation: a RE-LY (randomized evaluation of long-term anticoagulation therapy) trial analysis. Circulation. 2014;129:961–70.
Chin PK, Wright DF, Zhang M, Wallace MC, Roberts RL, Patterson DM, et al. Correlation between trough plasma dabigatran concentrations and estimates of glomerular filtration rate based on creatinine and cystatin C. Drugs R D. 2014;14:113–23.
de Lemos ML, Hsieh T, Hamata L, Levin A, Swenerton K, Djurdjev O, et al. Evaluation of predictive formulae for glomerular filtration rate for carboplatin dosing in gynecological malignancies. Gynecol Oncol. 2006;103:1063–9.
Ainsworth NL, Marshall A, Hatcher H, Whitehead L, Whitfield GA, Earl HM. Evaluation of glomerular filtration rate estimation by Cockcroft-Gault, Jelliffe, Wright and Modification of Diet in Renal Disease (MDRD) formulae in oncology patients. Ann Oncol. 2012;23:1845–53.
Craig AJ, Samol J, Heenan SD, Irwin AG, Britten A. Overestimation of carboplatin doses is avoided by radionuclide GFR measurement. Br J Cancer. 2012;107:1310–6.
Hartlev LB, Boeje CR, Bluhme H, Palshof T, Rehling M. Monitoring renal function during chemotherapy. Eur J Nucl Med Mol Imaging. 2012;39:1478–82.
Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, et al. Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer. Clin Genitourin Cancer. 2012;10:15–20.
Kaag D. Carboplatin dose calculation in lung cancer patients with low serum creatinine concentrations using CKD-EPI and Cockcroft-Gault with different weight descriptors. Lung Cancer. 2013;79:54–8.
Dooley MJ, Poole SG, Rischin D. Dosing of cytotoxic chemotherapy: impact of renal function estimates on dose. Ann Oncol. 2013;24:2746–52.
Pal SK, Ruel N, Villegas S, Chang M, DeWalt K, Wilson TG, et al. CKD-EPI and Cockcroft-Gault equations identify similar candidates for neoadjuvant chemotherapy in muscle-invasive bladder cancer. PLoS One. 2014;9:e94471.
Shepherd ST, Gillen G, Morrison P, Forte C, Macpherson IR, White JD, et al. Performance of formulae based estimates of glomerular filtration rate for carboplatin dosing in stage 1 seminoma. Eur J Cancer. 2014;50:944–52.
Cathomas R, Klingbiel D, Geldart TR, Mead GM, Ellis S, Wheater M, et al. Relevant risk of carboplatin underdosing in cancer patients with normal renal function using estimated GFR: lessons from a stage I seminoma cohort. Ann Oncol. 2014;25:1591–7.
Bennis Y, Savry A, Rocca M, Gauthier-Villano L, Pisano P, Pourroy B. Cisplatin dose adjustment in patients with renal impairment, which recommendations should we follow? Int J Clin Pharm. 2014;36:420–9.
Chew-Harris JS, Florkowski CM, George PM, Endre ZH. Comparative performances of the new chronic kidney disease epidemiology equations incorporating cystatin C for use in cancer patients. Asia Pac J Clin Oncol. 2014;11:142–51.
Moranville MP, Jennings HR. Implications of using modification of diet in renal disease versus Cockcroft-Gault equations for renal dosing adjustments. Am J Heal Syst Pharm. 2009;66:154–61.
McFarland MS, Markley BM, Zhang P, Hudson JQ. Evaluation of modification of diet in renal disease study and Cockcroft-Gault equations for sitagliptin dosing. J Nephrol. 2012;25:515–22.
Lessard BA, Zaiken K. Comparison of equations for dosing of medications requiring renal adjustment. J Am Pharm Assoc. 2013;53:54–7.
Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41.
KDIGO 2012. Clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1–150.
Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.
Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P. Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol. 2005;16:763–73.
Millar JA. The Cockroft and Gault formula for estimation of creatinine clearance: a friendly deconstruction. N Z Med J. 2012;125:119–22.
Piéroni L, Delanaye P, Boutten A, Bargnoux AS, Rozet E, Delatour V, et al. A multicentric evaluation of IDMS-traceable creatinine enzymatic assays. Clin Chim Acta. 2011;412:2070–5.
Delanaye P, Cavalier E, Cristol JP, Delanghe JR. Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate. J Nephrol. 2014;27:467–75.
Earley A, Miskulin D, Lamb EJ, Levey AS, Uhlig K. Estimating equations for glomerular filtration rate in the era of creatinine standardization: a systematic review. Ann Intern Med. 2012;156:785–95.
Matzke GR, Aronoff GR, Atkinson AJ Jr, Bennett WM, Decker BS, Eckardt K-UU, et al. Drug dosing consideration in patients with acute and chronic kidney disease: a clinical update from kidney disease: improving global outcomes (KDIGO). Kidney Int. 2011;80:1122–37.
Spruill WJ, Wade WE, Cobb HH III. Comparison of estimated glomerular filtration rate with estimated creatinine clearance in the dosing of drugs requiring adjustments in elderly patients with declining renal function. Am J Geriatr Pharmacother. 2008;6:153–60.
Nyman HA, Dowling TC, Hudson JQ, Peter WL, Joy MS, Nolin TD. Comparative evaluation of the Cockcroft-Gault equation and the modification of diet in renal disease (MDRD) study equation for drug dosing: an opinion of the Nephrology Practice and Research Network of the American College of Clinical Pharmacy. Pharmacotherapy. 2011;31:1130–44.
Nutescu EA, Spinler SA, Wittkowsky A, Dager WE. Low-molecular-weight heparins in renal impairment and obesity: available evidence and clinical practice recommendations across medical and surgical settings. Ann Pharmacother. 2009;43:1064–83.
Dowling TC, Matzke GR, Murphy JE, Burckart GJ. Evaluation of renal drug dosing: prescribing information and clinical pharmacist approaches. Pharmacotherapy. 2010;30:776–86.
Dufour B, Toussaint-Hacquard M, Kearney-Schwartz A, Manckoundia MD, Laurain MC, Joly L, et al. Glomerular filtration rate estimated by Cockcroft-Gault formula better predicts anti-Xa levels than modification of the diet in renal disease equation in older patients with prophylactic enoxaparin. J Nutr Health Aging. 2012;16:647–52.
Schaeffner ES, Ebert N, Delanaye P, Frei U, Gaedeke J, Jakob O, et al. Two novel equations to estimate kidney function in persons aged 70 years or older. Ann Intern Med. 2012;157:471–81.
Flamant M, Haymann JP, Vidal-Petiot E, Letavernier E, Clerici C, Boffa JJ, et al. GFR estimation using the Cockcroft-Gault, MDRD Study, and CKD-EPI equations in the elderly. Am J Kidney Dis. 2012;60:847–9.
Fotheringham J, Weatherley N, Kawar B, Fogarty DG, Ellam T. The body composition and excretory burden of lean, obese, and severely obese individuals has implications for the assessment of chronic kidney disease. Kidney Int. 2014;86:1221–8.
Du Bois D, Du Bois EF. A formula to estimate the approximative surface area if height and weight be known. Arch Intern Med. 1916;17:863–71.
Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Advance data from vital and health statistics; no 314. Hyattsville, Maryland: National Center for Health Statistics; 2000. www.cdc.gov/growthcharts.
Delanaye P, Krzesinski JM. Indexing of renal function parameters by body surface area: intelligence or folly? Nephron Clin Pract. 2011;119:c289–92.
Delanaye P, Cavalier E, Froissart M, Krzesinski J-MM. Reproducibility of GFR measured by chromium-51-EDTA and iohexol. Nephrol Dial Transplant. 2008;23:4077–8.
Stevens LA, Levey AS. Measured GFR as a confirmatory test for estimated GFR. J Am Soc Nephrol. 2009;20:2305–13.
Delanaye P, Cavalier E, Morel J, Mehdi M, Maillard N, Claisse G, et al. Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine. BMC Nephrol. 2014;15:9.
Pai MP. Treatment of bacterial infections in obese adult patients: how to appropriately manage antimicrobial dosage. Curr Opin Pharmacol. 2015;24:12–7.
Delanaye P, Mariat C, Maillard N, Krzesinski JM, Cavalier E. Are the creatinine-based equations accurate to estimate glomerular filtration rate in african american populations? Clin J Am Soc Nephrol. 2011;6:906–12.
DeCarolis DD, Thorson JG, Marraffa RA, Clairmont MA, Kuskowski MA. Comparison of equations with estimate renal function to predict serum vancomycin concentration in patients with spinal cord injury: does the use of cystatin C improve accuracy? Ther Drug Monit. 2014;36:632–9.
Frazee EN, Rule AD, Herrmann SM, Kashani KB, Leung N, Virk A, et al. Serum cystatin C predicts vancomycin trough levels better than serum creatinine in hospitalized patients: a cohort study. Crit Care. 2014;18:R110.
