Article (Scientific journals)
Computational modeling of bone fracture non-unions: four clinically relevant case studies.
Carlier, Aurelie; Lammens, Johan; Van Oosterwyck, Hans et al.
2015In In Silico Cell and Tissue Science, 2, p. 1
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Keywords :
Computational model; Fracture healing; Non-union
Abstract :
[en] The human skeleton has a remarkable regeneration capacity. Nevertheless, 5-10 % of the bone fractures fails to heal and develops into a non-union which is a challenging orthopedic complication requiring complex and expensive treatment. This review paper will discuss four different computational models, each capturing a particular clinical case of non-union: non-union induced by reaming of the marrow canal and periosteal stripping, non-union due to a large interfragmentary gap, non-union due to a genetic disorder [i.e. NF1 related congenital pseudoarthrosis of the tibia (CPT)] and non-union due to mechanical overload. Together, the four computational models are able to capture the etiology of a wide range of fracture non-union types and design novel treatment strategies thereof. Further research is required to corroborate the computational models in both animal and human settings and translate them from bench to bed side.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Carlier, Aurelie
Lammens, Johan
Van Oosterwyck, Hans
Geris, Liesbet  ;  Université de Liège > Département d'aérospatiale et mécanique > Génie biomécanique
Language :
English
Title :
Computational modeling of bone fracture non-unions: four clinically relevant case studies.
Publication date :
2015
Journal title :
In Silico Cell and Tissue Science
eISSN :
2196-050X
Publisher :
SpringerOpen, Heidelberg, Germany
Volume :
2
Pages :
1
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 279100 - BRIDGE - Biomimetic process design for tissue regeneration: from bench to bedside via in silico modelling
Funders :
CE - Commission Européenne [BE]
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since 16 July 2016

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