Article (Scientific journals)
Prevalence of vitamin D inadequacy in European postmenopausal women
Bruyère, Olivier; Malaise, Olivier; NEUPREZ, Audrey et al.
2007In Current Medical Research and Opinion, 23 (8), p. 1939-1944
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Keywords :
osteoporosis; postmenopausal women; prevalence; vitamin D deficiency
Abstract :
[en] Objective: Inadequate vitamin D level is associated with secondary hyperparathyroidism and increased bone turnover and bone loss, which in turn increases fracture risk. The objective of this study is to assess the prevalence of inadequate serum vitamin D levels in postmenopausal European women. There are no clear international agreements on what constitutes a level of vitamin D inadequacy, but recent publications suggest that the circulating level of vitamin D should be over 80 nmol/L or at least between 50 and 80 nmol/L. Material and methods: Assessment of 25-hydroxyvitamin D [25(OH)D] was performed in 8532 European postmenopausal women with osteoporosis or osteopenia. European countries included France, Belgium, Denmark, Italy, Poland, Hungary, United Kingdom, Spain and Germany. Two cut-offs of 25(OH)D inadequacy were fixed < 80 nmol/L and < 50 nmol/L. Results: Mean (SD) age of the patients was 74.2 (7.1) years, body mass index was 25.7 (4.1)kg/m(2). Level of 25(OH)D was 61.0 (27.2) nmol/L. There was a highly significant difference of 25(OH)D level across European countries (p < 0.0001). The lowest level of 25(OH)D was found in France [51.5 (26.1) nmol/L] and the highest in Spain [85.2 (33.3) nmol/L]. In the whole study population, the prevalence of 25(OH)D inadequacy was 79.6% and 32.1 % when considering cut-offs of 80 and 50 nmol/L, respectively and when considering patients aged less than 65 years, the prevalence reached 86% (cut-off of 80 nmol/L) and 45% (cutoff of 50 nmol/L). Conclusion: This study indicates a high prevalence of vitamin D [25(OH)D] inadequacy in European postmenopausal women. The prevalence could be even higher in some particular countries. A greater awareness of the importance of vitamin D inadequacy is needed to address this public health problem.
Disciplines :
Laboratory medicine & medical technology
General & internal medicine
Author, co-author :
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Malaise, Olivier ;  Université de Liège - ULiège > Cert.ECG
NEUPREZ, Audrey ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Collette, Julien ;  Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Language :
English
Title :
Prevalence of vitamin D inadequacy in European postmenopausal women
Publication date :
August 2007
Journal title :
Current Medical Research and Opinion
ISSN :
0300-7995
eISSN :
1473-4877
Publisher :
Librapharm, Newbury, United Kingdom
Volume :
23
Issue :
8
Pages :
1939-1944
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 August 2009

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