High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study

Edwards, M.H.; Parsons, C.; Bruyère, Olivier; Petit Dop, F.; Chapurlat, R.; Roemer, F.W.; Guermazi, A.; Zaim, S.; Genant, H.; Reginster, Jean-Yves; Dennison, E.M.; Cooper, C.; The SEKOIA Study Group

doi:10.3899/jrheum.150053

Article (Scientific journals)

High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study

Edwards, M.H.; Parsons, C.; Bruyère, Olivier et al.

2016 • In Journal of Rheumatology, 43 (3), p. 657-65

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https://hdl.handle.net/2268/198514

DOI
10.3899/jrheum.150053

PubMed
26773120

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Keywords :

Osteoarthritis; knee; progression; Natural History; Magnetic Resonance Imaging; Radiographic; Joint Space Narrowing

Abstract :

[en] Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW). Methods. A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression. Results. The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = –0.10 (95% CI –0.18, –0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW. Conclusion. The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade. (First Release January 15 2016; J Rheumatol 2016;43:657–65; doi:10.3899/jrheum.150053)

Disciplines :

Rheumatology
Public health, health care sciences & services

Author, co-author :

Edwards, M.H.

Parsons, C.

Bruyère, Olivier ; Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Petit Dop, F.

Chapurlat, R.

Roemer, F.W.

Guermazi, A.

Zaim, S.

Genant, H.

Reginster, Jean-Yves ; Université de Liège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

More authors (3 more)

Language :

English

Title :

High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study

Publication date :

2016

Journal title :

Journal of Rheumatology

ISSN :

0315-162X

eISSN :

1499-2752

Publisher :

Journal of Rheumatology Publishing Company, Toronto, Canada

Volume :

Issue :

Pages :

657-65

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 June 2016

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