Article (Scientific journals)
Hematies Hyperdenses et Sphérocytose
Bricteux, Guy; Panagopoulos, A.; Paulus, Jean-Michel
2002In Revue Médicale de Liège, 57 (7), p. 443-8
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Keywords :
Hyperdense red blood cells; Hereditary spherocytosis; Hyperchromic red blood cells
Abstract :
[en] A 12-year old female, suffering from recurring episodes of icterus and abdominal pain, is hospitalized in emergency. She is not anemic but her hemogram reveals a high level of hyperdense red blood cells (32%; controls 0-2.5%) and an abnormal reticulocyte count (201 x 10(3)/microL; controls 29-84 x 10(3)/microL), indicating a 3.5 fold increase in RBC production. The same abnormalities are found in the patient's mother. The blood smear shows few spherocytes. RBC osmotic fragility is increased only after incubation. Hereditary spherocytosis is diagnosed following electrophoresis of membrane proteins which reveals a deficiency in band 3, a protein which links the lipid bilayer to the cytoskeleton. This case of hemolytic anemia-illustrates the physiopathologic and diagnostic significance of hyperdense RBC, which reflect the cell dehydration associated with the membrane disorder.
Disciplines :
Hematology
Author, co-author :
Bricteux, Guy ;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie
Panagopoulos, A.
Paulus, Jean-Michel ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
French
Title :
Hematies Hyperdenses et Sphérocytose
Alternative titles :
[en] Hyperdense Red Blood Cells and Spherocytosis
Publication date :
July 2002
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
57
Issue :
7
Pages :
443-8
Peer reviewed :
Peer reviewed
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