Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

[en] The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

Disciplines :

Pharmacy, pharmacology & toxicology
Chemistry

Author, co-author :

Manos-Turvey, Alexandra ; University of Pittsburgh -PITT > Department of Biological Sciences and Department of Chemistry

Watson, Emma E.

Sykes, Melissa L.

Jones, Amy J.

Baell, Jonathan B.

Kaiser, Marcel

Avery, Vicky M.

Payne, Richard J.

Language :

English

Title :

Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

Publication date :

2015

Journal title :

MedChemComm

ISSN :

2040-2503

eISSN :

2040-2511

Publisher :

Royal Society of Chemistry, London, United Kingdom

Volume :

Issue :

Pages :

403-406

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://dx.doi.org/10.1039/C4MD00406J

Available on ORBi :

since 03 June 2016

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