The TB Structural Genomics Consortium: A decade of progress

[en] Summary The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein–protein and protein–ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design.

Disciplines :

Immunology & infectious disease

Author, co-author :

Chim, Nicholas

Habel, Jeff E.

Johnston, Jodie M.

Krieger, Inna

Miallau, Linda

Sankaranarayanan, Ramasamy

Morse, Robert P.

Bruning, John

Swanson, Stephanie

Kim, Haelee

More authors (13 more)

Language :

English

Title :

The TB Structural Genomics Consortium: A decade of progress

Publication date :

2011

Journal title :

Tuberculosis

ISSN :

1472-9792

Publisher :

Churchill Livingstone, United States

Volume :

Issue :

Pages :

155-172

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science/article/pii/S1472979210001381

Available on ORBi :

since 03 June 2016

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