Article (Scientific journals)
Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.
Bay-Jensen, A. C.; Reker, D.; Kjelgaard-Petersen, C. F. et al.
2016In Osteoarthritis and Cartilage, 24 (1), p. 9-20
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Keywords :
BIPED; Biomarkers; Osteoarthritis (OA); Year in a review
Abstract :
[en] OBJECTIVE: To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of osteoarthritis (OA). Furthermore, to summarize the BIPED criteria and set it in context of the medical needs of 2015. METHODS: PubMed was used as searching machine: Time period 2014/04/01-2015/05/01, MeSH term [Biomarker] AND [Osteoarthritis], Language; English, Full text available. Reviews were excluded. Only papers describing protein based biomarkers measured in human body fluids from OA patients were included. RESULTS: Biomarkers of joint tissue turnover, cytokines, chemokines and peptide arrays were measured in different cohorts and studies. Amongst those were previously tested biomarkers such as osteocalcin, Carboxy-terminal cross-linked fragment of type II collagen (CTX-II) and cartilage oligomeric matrix protein (COMP). A majority of the biomarker were classified as I, B or B biomarkers according to the BIPED criteria. Work is continuing on testing biomarkers in OA. There is still a huge, unmet medical need to identify, test, validate and qualify novel and well-known biomarkers. A pre-requisite for this is better characterization and classification of biomarkers to their needs, which may not be reached before higher understanding of OA phenotypes has been gained. In addition, we provide some references to some recent guidelines from Food and Drug Administration (FDA) and European Medicines Agency (EMA) on qualification and usage of biomarkers for drug development and personalized medicine, which may provide value to the field.
Disciplines :
Rheumatology
Author, co-author :
Bay-Jensen, A. C.
Reker, D.
Kjelgaard-Petersen, C. F.
Mobasheri, A.
Karsdal, M. A.
Ladel, C.
Henrotin, Yves  ;  Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Thudium, C. S.
Language :
English
Title :
Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria.
Publication date :
2016
Journal title :
Osteoarthritis and Cartilage
ISSN :
1063-4584
eISSN :
1522-9653
Publisher :
Elsevier, United Kingdom
Volume :
24
Issue :
1
Pages :
9-20
Peer reviewed :
Peer Reviewed verified by ORBi
European Projects :
FP7 - 305815 - D-BOARD - Novel Diagnostics and Biomarkers for Early Identification of Chronic Inflammatory Joint Diseases
Funders :
CE - Commission Européenne [BE]
Commentary :
Copyright (c) 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.
Available on ORBi :
since 27 May 2016

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