The Effects of Hypertonic Saline in Healthy and Diseased Animals

[en] In this review, the pharmacological effects of administering hypertonic solutions to both healthy animals and during experimentally induced diseases are considered with a view to understanding the mechanisms behind the possible clinical efficacy of such treatment. The review focuses successively on haemorrhagic shock, endotoxic shock and hypokalaemic metabolic alkalosis. How hypertonic saline solutions affect oxygen transport by haemoglobin is also considered.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Cambier, Carole ; Université de Liège - ULiège > Département de sciences fonctionnelles > Département de sciences fonctionnelles

Ratz, V.

Rollin, Frédéric ; Université de Liège - ULiège > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs

Frans, A.

Clerbaux, T.

Gustin, Pascal ; Université de Liège - ULiège > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie

Language :

English

Title :

The Effects of Hypertonic Saline in Healthy and Diseased Animals

Publication date :

1997

Journal title :

Veterinary Research Communications

ISSN :

0165-7380

Publisher :

Kluwer Academic Publishers, Dordrecht, Netherlands

Volume :

Issue :

Pages :

303-316

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 August 2009

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Bibliography

Bertone, J.J., Gossett, K.A., Shoemaker, K.E., Bertone, A.L. and Schneiter, H.L., 1990. Effect of hypertonic vs isotonic saline solution on responses to sublethal Escherichia coli endotoxemia in horses. American Journal of Veterinary Research, 51, 999-1007
Brown, J.M., Grosso, M.A. and Moore, E.E., 1990. Hypertonic saline and dextran: impact of cardiac function in the isolated rat heart. The Journal of Trauma, 30, 646-651
Chien, S., Dellenback, R.J., Usami, S., Treitel, K., Chang, G. and Gregersen, M.I., 1966. Blood volume and its distribution in endotoxin shock. American Journal of Physiology, 210, 1411-1418
Clerbaux, Th., Gustin, P., Detry, B., Cao, M.L. and Frans, A., 1993. Comparative study of the oxyhaemoglobin dissociation curve in four mammals: man, dog, horse and cattle. Comparative Biochemistry and Physiology, 106A, 687-694
Constable, P.D., Schmall, L.M., Muir III, W.W., Hoffsis, G.F. and Shertel, E.R., 1991a. Hemodynamic response of endotoxemic calves to treatment with small-volume hypertonic saline solutions. American Journal of Veterinary Research, 52, 981-989
Constable, P.D., Schmall, L.M., Muir III, W.W. and Hoffsis, G.F., 1991b. Respiratory, renal, hematologic, and serum biochemical effects of hypertonic saline solution in endotoxemic calves. American Journal of Veterinary Research, 52, 990-998
Constable, P.D., Muir III, W.W. and Hoffsis, G.F., 1994. Hypertonic saline is a negative inotropic agent in normovolumic dogs. American Journal of Physiology, 267, H667-H677
Fenner, W.R., 1991. Shock. In: Quick Reference to Veterinary Medicine, 2nd edn, (J.B. Lippincott, Philadelphia), 3-11
Friedman, G.S., Pearce, F.J. and Drucker, W.R., 1982. The role of blood glucose in defense of plasma volume during hemorrhage. The Journal of Trauma, 22, 86-91
Fronticelli, C., 1990. A possible new mechanism of oxygen affinity modulation in mammalian hemoglobins. Biophysical Chemistry, 37, 141-146
Fubini, S.L., Smith, D.F., Grohn, Y.T., Levine, S.A. and Deuel, D.M., 1991. Replacement of chloride deficit by use of 1.8% NaCl to correct experimentally induced hypochloremic metabolic alkalosis in sheep. American Journal of Veterinary Research, 52, 1898-1902
Gasthuys, F., 1994. The value of 7.2% hypertonic saline solution in anesthesia and intensive care: myth or fact? Journal of Veterinary Anesthesiology, 21, 12-14
Gazitua, S., Scott, J.B., Chou, C.C. and Haddy, F.J., 1969. Effect of osmolarity on canine renal vascular resistance. American Journal of Physiology, 217, 1216-1223
Gazitua, S., Scott, J.B., Swindall, B. and Haddy, F.J., 1971. Resistance responses to local changes in plasma osmolality in three vascular beds. American Journal of Physiology, 220, 384-391
Gustin, P., Clerbaux, Th., Willems, E., Lekeux, P., Lomba, F. and Frans, A., 1988. Oxygen transport properties of blood in two different bovine breeds. Comparative Biochemistry and Physiology, 89A, 553-558
Gustin, P., Detry, B., Cao, M.L., Chenut, F., Robert, A., Ansay, M., Frans, A. and Clerbaux, T., 1994. Chloride and inorganic phosphate modulate binding of oxygen to bovine red blood cells. Journal of Applied Physiology, 77, 202-208
Hands, R., Holcroft, J.W., Perron, P.R. and Kramer, G.C., 1988. Comparison of peripheral and central infusions of 7.5% NaCl/6% dextran 70. Surgery, 103, 684-689
Hellyer, P.W. and Meyer, R.E., 1994. Effects of hypertonic saline on myocardial contractility in anaesthetized pigs. Journal of Veterinary Pharmacology and Therapeutics, 17, 211-217
Holcroft, J.W., Vassar, M.J., Turner, J.E., Derlet, R.W. and Kramer, G.C., 1987. 3% NaCl and 7.5% NaCl/ Dextran 70 in the resuscitation of severely injured patients. Annals of Surgery, 206, 279-288
Järhult, J., 1975. Osmolar control of the circulation in hemorrhagic hypotension. Acta Physiologica Scandinavica, Supplementum, 423, 3-83
Kien, N.D., Kramer, G.C. and White, D.A., 1991a. Acute hypotension caused by rapid hypertonic saline infusion in anesthetized dogs. Anesthesia and Analgesia, 73, 597-602
Kien, N.D., Reitan, J.A., White, D.A., Chih-Hsiung Wu and Eisele, J.H., 1991b. Cardiac contractility and blood flow distribution following resuscitation with 7.5% hypertonic saline in anesthetized dogs. Circulatory Shock, 35, 109-116
Kramer, G.C., Perron, P.R., Lindsey, D.G., Hung Sy Ho, Gunther, R.A., Boyle, W.A. and Holcroft, J.W., 1986. Small-volume resuscitation with hypertonic saline dextran solution. Surgery, 100, 239-246
Kreimeier, U., Frey, L., Dentz, J., Herbel, T. and Messner, K., 1991. Hypertonic saline dextran resuscitation during the initial phase of acute endotoxemia: effect on regional blood flow. Critical Care Medicine, 19, 801-809
Lopes, O.U., Pontieri, V., Rocha-e-Silva, M. and Velasco, I.T., 1981. Hyperosmotic NaCl and severe hemorrhagic shock: role of the innervated lung. American Journal of Physiology, 241, 833-890
Lopes, O.U., Velasco, I.T., Guertzenstein, P.G., Rocha-e-Silva, M. and Velasco, I.T., 1986. Hypertonic NaCl restores mean circulatory filling pressure in severely hypovolemic dogs. Hypertension, Supplement I, 195-199
Luypaert, P., Vincent, J.-L., Domb, M., Van der Linden, P., Blecic, S., Azimi, G. and Bernard, A., 1986. Fluid resuscitation with hypertonic saline in endotoxic shock. Circulatory Shock, 20, 311-320
Maningas, P.A., De Guzman, L.R., Tillman, F.J., Hinson, C.S., Priegnitz, K.J., Volk, K.A. and Bellamy, R.F., 1986. Small-volume infusion of 7.5% NaCl in 6% dextran 70R for the treatment of severe hemorrhagic shock in swine. Annals of Emergency Medicine, 15, 1131-1137
Mazzoni, M.C., Borgström, P., Arfors, K.E. and Intaglietta, M., 1988. Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage. American Journal of Physiology, 255, H629-H637
Muir III, W.W. and Sally, J., 1989. Small-volume resuscitation with hypertonic saline solution in hypovolemic cats. American Journal of Veterinary Research, 50, 1883-1888
Mullins, R.J. and Hudgens, R.W., 1987. Hypertonic saline resuscitates dogs in endotoxin shock. Journal of Surgical Research, 43, 37-44
Nakayama, Shin-ichi, Sibley, L., Gunther, R.A., Holcroft, J.W. and Kramer, G.C., 1984. Small-volume resuscitation with hypertonic saline (2400 mOsm/liter) during hemorrhagic shock. Circulatory Shock, 13, 149-159
Newell, J.D., Higgins, C.B., Kelley, M. J., Green, C.E., Schmidt, W.S. and Haigler, F., 1980. The influence of hyperosmolality on left ventricular contractile state: disparate effects of nonionic and ionic solutions. Investigative Radiology, 15, 363-370
Olson, N.C. and Brown, Jr., T.T., 1985. Effects of endotoxemia on lung water and hemodynamics in conscious calves. American Journal of Veterinary Research, 46, 711-718
Prough, D.S., Johnson, J.C., Stullken, E.H., Stump, D.A., Poole, G.V. and Howard, G., 1985. Effects on cerebral hemodynamics of resuscitation from endotoxic shock with hypertonic saline versus lactated Ringer's solution. Critical Care Medicine, 13, 1040-1044
Renck, H., Ljungström, K.G., Hedin, H. and Richter, W., 1983. Prevention of dextran-induced anaphylactic reactions by hapten inhibition. Acta Chirurgica Scandinavica, 149, 355-360
Richards, A.M., Ikram, K., Yandle, T.G., Nicholls, M.G., Webster, M.W.I. and Espiner, E.A., 1985. Renal, haemodynamic and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers. The Lancet, i, 545-549
Ring, J. and Messmer, K., 1977. Incidence and severity of anaphylactoid reactions to colloid volumes substitutes. The Lancet, i, 466-469
Rocha-e-Silva, M., Negraes, G.A., Soares, A.M., Pontieri, V. and Loppnow, L., 1986. Hypertonic resuscitation from severe hemorrhagic shock: patterns of regional circulation. Circulatory Shock, 19, 165-175
Rocha-e-Silva, M., Velasco, I.T., Nogueira da Silva, R.I., Oliveira, M.A., Negraes, G.A. and Oliveira, M.A., 1987. Hyperosmotic sodium salts reverse severe hemorrhagic shock: other solutes do not. American Journal of Physiology, 253, 751-762
Rowe, G.G., McKenna, D.H., Corliss, R.J. and Sialer, S., 1972. Hemodynamic effects of hypertonic sodium chloride. Journal of Applied Physiology, 32, 182-184
Schmall, L.M., Muir, W.W. and Robertson, J.T., 1990a. Haemodynamic effects of small volume hypertonic saline in experimentally induced haemorrhagic shock. Equine Veterinary Journal, 22, 273-277
Schmall, L.M., Muir, W.W. and Robertson, J.T., 1990b. Haematological, serum electrolyte and blood gas effects of small volume hypertonic saline in experimentally induced haemorrhagic shock. Equine Veterinary Journal, 22(4), 278-283
Schertel, E.R., Valentine, A.K., Rademakers, A.M. and Muir, W.W., 1990. Influence of 7% NaCl on the mechanical properties of the systemic circulation in the hypovolemic dog. Circulatory Shock, 31, 203-214
Smith, G.J., Kramer, G.C., Perron, P., Nakayama, Shin-ichi, Gunther, R.A. and Holcroft, J.W., 1985. A comparison of several hypertonic solutions for resuscitation of bled sheep. Journal of Surgical Research, 39, 517-528
Stiff, J.L., Munch, D.F. and Bromberger-Barnea, B., 1979. Hypotension and respiratory distress caused by rapid infusion of mannitol or hypertonic saline. Anesthesia and Analgesia, 58, 42-48
Szczepanska-Sadowska, E., Sobocinska, J. and Kozlowski, S., 1979. Thirst and renal excretion of water and electrolytes during pyrogen fever in dogs. Archives Internationales de Physiologie et de Biochimie, 87, 673-686
Traverso, L.W., Bellamy, R.F., Hollenbach, S.J. and Witcher, L.D., 1987. Hypertonic sodium chloride solutions: effect on hemodynamics and survival after hemorrhage in swine. The Journal of Trauma, 27, 32-39
Velasco, I.T., Pontieri, V., Rocha-e-Silva, M. and Lopes, O.U., 1980. Hyperosmotic NaCl and severe hemorrhagic shock. American Journal of Physiology, 239, H664-H673
Walsh, J.C. and Kramer, G.C., 1991. Resuscitation of hypovolemic sheep with hypertonic saline/dextran: the role of dextran. Circulatory Shock, 34, 336-343
Ward, J.L., Smith, D.F., Fubini, S.L. and Gröhn, Y.T., 1993. Comparison of 0.9, 3.6 and 7.2% NaCl for correction of experimentally induced hypochloremic, hypokalemic metabolic alkalosis in sheep. American Journal of Veterinary Research, 54, 1160-1169
Younes, R.N., Aun, F., Tomida, R.M. and Birolini, D., 1985. The role of lung innervation in the hemodynamic response to hypertonic sodium chloride solutions in hemorrhagic shock. Surgery, 98, 900-906