Mechanisms of HTLV-1 persistence and transformation.

Basic-Leucine Zipper Transcription Factors/physiology; Cell Transformation, Viral; DNA Damage; Gene Products, rex/physiology; Gene Products, tax/physiology; Genomic Instability; Human T-lymphotropic virus 1/genetics/physiology; Humans; Leukemia-Lymphoma, Adult T-Cell/pathology/virology; T-Lymphocytes/pathology; Viral Proteins/physiology; Virus Replication

Abstract :

[en] Adult T-cell leukaemia (ATL) is caused by the human T-cell lymphotropic virus type 1 (HTLV-1). HTLV-1 has elaborated strategies to persist and replicate in the presence of a strong immune response. In this review, we summarise these mechanisms and their contribution to T-cell transformation and ATL development.

Disciplines :

Oncology

Author, co-author :

Boxus, Mathieu ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Willems, Luc ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

Mechanisms of HTLV-1 persistence and transformation.

Publication date :

2009

Journal title :

British Journal of Cancer

ISSN :

0007-0920

eISSN :

1532-1827

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

101

Issue :

Pages :

1497-501

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 January 2010

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79 (9 by ULiège)

Number of downloads

4 (2 by ULiège)

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Scopus citations^®

106

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

126

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