[en] laryngeal and vocal results obtained after microflap excision of benign vocal fold lesions and immediate implantation of esterified hyaluronic acid(EHA) in the surgical wound are described in this study. Prospective and comparative study on 83 patients ( 33 implanted with EHA and 50 not implanted). Longest follow up is 4 years. The objectives are to confirm the innocuity of the technique, to demonstrate the laryngeal and vocal evolution at short and long term, and to evaluate the eventual positive impact of EHA implantation on the pliability of the superficial layer of the lamina propria (SLLP) and on voice. The use of EHA implant in microdissected SLLP is safe and leads to good laryngeal and vocal outcomes in the treated patients.
Disciplines :
Otolaryngology
Author, co-author :
FINCK, Camille ; Centre Hospitalier Universitaire de Liège - CHU > O.R.L.
P.D. Ward, S.L. Thibeault, and S.D. Gray Hyaluronic acid: its role in voice J Voice 16 2002 303 309
J.E. Butler, T.H. Hammond, and S.D. Gray Gender-related differences of hyaluronic acid distribution in the human vocal fold Laryngoscope 111 2001 907 911
S.D. Gray, I.R. Titze, R. Chan, and T.H. Hammond Vocal fold proteoglycans and their influence on biomechanics Laryngoscope 109 1999 845 854
R.W. Chan, S.D. Gray, and I.R. Titze The importance of hyaluronic acid in vocal fold biomechanics Otolaryngol Head Neck Surg 124 2001 607 614
E.A. Balazs, and N.E. Larsen Hyaluronan: aiming for perfect skin regeneration H.G. Garg, Scarless Wound Healing 2000 Marcel Dekker New York 143 160
S.L. Thibeault, B. Rousseau, N.V. Welham, S. Hirano, and D.M. Bless Hyaluronan levels in acute vocal fold scar Laryngoscope 114 2004 760 764
C. Finck, and P. Lefebvre Implantation of esterified hyaluronic acid in microdissected Reinke's space after vocal fold microsurgery: first clinical experiences Laryngoscope 115 2005 1841 1847
V. Uloza Effects on voice by endolaryngeal microsurgery Eur Arch Otorhinolaryngol 256 1999 312 315
P. Woo, J. Casper, R. Colton, and D. Brewer Aerodynamic and stroboscopic findings before and after microlaryngeal phonosurgery J Voice 8 1994 186 194
S.M. Zeitels, R.E. Hillman, G.W. Bunting, and T. Vaughn Reinke's edema: phonatory mechanisms and management strategies Ann Otol Rhinol Laryngol 106 7 Pt 1 1997 533 543
R.W. Chan, and I.R. Titze Viscosities of implantable biomaterials in vocal fold augmentation surgery Laryngoscope 108 1998 725 731
S. Hertegrd, L. Hallén, C. Laurent, E. Lindström, K. Olofsson, P. Testad, and A. Dahlqvist Cross-linked hyaluronan versus collagen for injection treatment of glottal insufficiency: 2-year follow-up Acta Otolaryngol 124 2004 1208 1214
T. Caton, S.L. Thibeault, S. Klemuk, and M.E. Smith Viscoelasticity of hyaluronan and nonhyaluronan based vocal fold injectables: implications for mucosal versus muscle use Laryngoscope 117 2007 516 521
R.W. Chan, and I.R. Titze Hyaluronic acid (with fibronectin) as a bioimplant for the vocal fold mucosa Laryngoscope 109 7 Pt 1 1999 1142 1149
R.W. Chan, and I.R. Titze Viscoelastic shear properties of human vocal fold mucosa: measurement methodology and empirical results J Acoust Soc Am 106 4 Pt 1 1999 2008 2021
S.A. Klemuk, and I.R. Titze Viscoelastic properties of three vocal-fold injectable biomaterials at low audio frequencies Laryngoscope 114 2004 1597 1603
L. Hallen, A. Dahlqvist, and C. Laurent Dextranomeres in hyaluronan (DiHA): a promising substance in treating vocal cord insufficiency Laryngoscope 108 1998 393 397
L. Hallen, P. Testad, E. Sederholm, A. Dahlqvist, and C. Laurent DiHA (dextranomers in hyaluronan) injections for treatment of insufficient closure of the vocal folds: early clinical experiences Laryngoscope 111 2001 1063 1067
S. Hertegrd, L. Hallén, C. Laurent, E. Lindström, K. Olofsson, P. Testad, and A. Dahlqvist Cross-linked hyaluronan used as augmentation substance for treatment of glottal insufficiency: safety aspects and vocal fold function Laryngoscope 112 2002 2211 2219
M.W. Hsiung, Y.S. Lin, W.F. Su, J.C. Lee, and H.W. Wang Fat augmentation following microsurgical removal of the vocal nodules: long-term results ORL J Otorhinolaryngol Relat Spec 65 2003 169 175
M.T. Longaker, E.S. Chiu, N.S. Adzick, M. Stern, M.R. Harrison, and R. Stern Studies in fetal wound healing. V. A prolonged presence of hyaluronic acid characterizes fetal wound fluid Ann Surg 213 1991 292 296
L.L. Huang-Lee, J.H. Wu, and M.E. Nimni Effects of hyaluronan on collagen fibrillar matrix contraction by fibroblasts J Biomed Mater Res 28 1994 123 132
N. Rydell Decreased granulation tissue reaction after installment of hyaluronic acid Acta Orthop Scand 41 1970 307 311
S.R. King, W.L. Hickerson, and K.G. Proctor Beneficial actions of exogenous hyaluronic acid on wound healing Surgery 109 1991 76 84
A.J. Day, and G.D. Prestwich Hyaluronan-binding proteins: tying up the giant J Biol Chem 277 2002 4585 4588
R. Savani, D.J. Bagli, R.E. Harrisson, and E.A. Turley The role of hyaluronan receptor interactions in wound repair Scarless Wound Healing 2000 Marcel Dekker New York 115 137
F. Wang, L.A. Garza, S. Kang, J. Varari, J.S. Orringer, G.J. Fisher, and J.J. Voorhees In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photo-damaged human skin Arch Dermatol 143 2007 155 163
K. Breuing, E. Eriksson, P. Liu, and D. Miller Healing of partial thickness porcine wounds in a liquid environment J Surg Res 52 1991 50 58
F. Arnold, C. Jia, G.W. Cherry, B. Carbow, W. Meyer-Ingold, B. Bader, and D.C. Wes Hyaluronan, heterogenity and healing: the effects of ultrapure hyaluronan of defined molecular size on the repair of full-thickness pig skin wounds Wound Repair Regen 3 1995 299 310
P. Andre Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA - Q-Medical, Sweden) in European countries: a retrospective study from 1997 to 2001 J Eur Acad Dermatol Venereol 18 2004 422 425