Do insulin resistance and inflammation at rest exacerbate the post-exercise oxidative stress in Lebanese overweight adolescent girls?

Introduction. -The goal of this study was to check if exercise raises oxidative stress markers in overweight teenagers (n = 29) compared to non obese (n = 17) ones. Synthesis. -Blood markers of insulin resistance, inflammation and oxidative stress were measured at rest and/or after a maximal exercise. At rest, the overweight teenagers exhibited an insulin resistance, an inflammation and an oxidative stress. After exercise, plasmatic myeloperoxidase and lipid hydroperoxides were increased only in overweight teenagers. However, the differences between groups disappeared when the values were reported to VO2 Pie suggesting that exercise intensity consitutes the major oxidative stress factor. Conclusions. -The relations between rest insulin resistance, inflammation and post-exercise oxidative stress indicate that those parameters contribute in post-exercise oxidative stress. (C) 2007 Elsevier Masson SAS. Tons droits reserves.