RELMs in the Realm of Helminths

[en] Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus brasiliensis using a double knockout system. The study highlighted how important and yet divergent the contributions of these proteins are in the control of helminth infections.

Disciplines :

Immunology & infectious disease

Author, co-author :

Horsnell, William G. C.; University of Cape Town > Division of Immunology

Dewals, Benjamin G ; Université de Liège > Immunologie et vaccinologie

Language :

English

Title :

RELMs in the Realm of Helminths

Publication date :

April 2016

Journal title :

Trends in Parasitology

ISSN :

1471-4922

eISSN :

1471-5007

Publisher :

Elsevier, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 02 May 2016

Statistics

Number of views

55 (9 by ULiège)

Number of downloads

0 (0 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Nair M.G., et al. Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung. J. Exp. Med. 2009, 206:937-952.
Herbert D.R., et al. Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection. J. Exp. Med. 2009, 206:2947-2957.
Pesce J.T., et al. Retnla (Relmα/Fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog. 2009, 5:e1000393.
Jang J.C., et al. Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. PLoS Pathog. 2015, 11:e1004579.
Chen G., et al. Comparison of RELMα and RELMβ single- and double-gene-deficient mice reveals that RELMα expression dictates inflammation and worm expulsion in hookworm infection. Infect. Immun. 2016, 84:1100-1111.
Cook P.C., et al. Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:9977-9982.
Liu T., et al. Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6. J. Immunol. 2004, 173:3425-3431.
Gerbe F., et al. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature 2016, 529:226-230.
Artis D., et al. RELMβ/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:13596-13600.
Thawer S., et al. Surfactant protein-D is essential for immunity to helminth infection. PLoS Pathog. 2016, 12:e1005461.