Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite

[en] Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.

Disciplines :

Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others

Author, co-author :

Ozhukil Kollath, Vinayaraj

Mullens, Steven

Luyten, Jan

Traina, Karl ; Université de Liège - ULiège > Département de chimie (sciences) > LCIS - GreenMAT

Cloots, Rudi ; Université de Liège > Département de chimie (sciences) > LCIS - GreenMAT

Language :

English

Title :

Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite

Publication date :

11 March 2016

Journal title :

Materials Technology: Advanced Performance Materials

ISSN :

1066-7857

eISSN :

1753-5557

Publisher :

Taylor & Francis, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.tandfonline.com/doi/abs/10.1179/1753555715Y.0000000048

Available on ORBi :

since 21 April 2016

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