Article (Scientific journals)
Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
Ozhukil Kollath, Vinayaraj; Mullens, Steven; Luyten, Jan et al.
2016In Materials Technology: Advanced Performance Materials
Peer Reviewed verified by ORBi
 

Files


Full Text
OzhukilKollath_MTE545_author-postprint.pdf
Author postprint (839.3 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
hydroxyapatite; dopamine; protein; adsorption; oral delivery; carrier
Abstract :
[en] Hydroxyapatite (HA) is a promising carrier material for oral delivery of biomolecules such as proteins and drugs. Ways to increase the loading of such molecules on HA will lead to better nanomedicine. This study reports the surface functionalisation of HA particles using the mussel inspired molecules dopamine (DA) and 3,4-dihydroxy-L-phenylalanine (DOPA), in order to increase protein loading. The adsorption mechanisms are discussed based on the adsorption isotherms, zeta potential, thermal analysis and theoretical models. Results show that DA functionalisation enhanced the loading, while DOPA functionalisation was ineffective.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Ozhukil Kollath, Vinayaraj 
Mullens, Steven
Luyten, Jan
Traina, Karl ;  Université de Liège - ULiège > Département de chimie (sciences) > LCIS - GreenMAT
Cloots, Rudi ;  Université de Liège > Département de chimie (sciences) > LCIS - GreenMAT
Language :
English
Title :
Effect of DOPA and dopamine coupling on protein loading of hydroxyapatite
Publication date :
11 March 2016
Journal title :
Materials Technology: Advanced Performance Materials
ISSN :
1066-7857
eISSN :
1753-5557
Publisher :
Taylor & Francis, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 April 2016

Statistics


Number of views
78 (17 by ULiège)
Number of downloads
104 (1 by ULiège)

Scopus citations®
 
7
Scopus citations®
without self-citations
7
OpenCitations
 
5

Bibliography


Similar publications



Contact ORBi