Herman-Giddens ME, Slora EJ, Wasserman RC, Bourdony CJ, Bhapkar MV, Koch GG, Hasemeier CM. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics 1997; 99: 505-512
Aksglaede L, Sorensen K, Petersen JH, Skakkebaek NE, Juul A. Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 2009; 123: e932-e939
Herman-Giddens ME, Steffes J, Harris D, Slora E, Hussey M, Dowshen SA, Wasserman R, Serwint JR, Smitherman L, Reiter EO. Secondary sexual characteristics in boys: data from the Pediatric Research in Office Settings Network. Pediatrics 2012; 130: e1058-e1068
Krstevska-Konstantinova M, Charlier C, Craen M, Du Caju M, Heinrichs C, De Beaufort C, Plomteux G, Bourguignon JP. Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum Reprod 2001; 16: 1020-1026
Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP. The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocrine Rev 2001; 24: 668-693
Wohlfahrt-Veje C, Andersen HR, Schmidt IM, Aksglaede L, Sorensen K, Juul A, Jensen TK, Grandjean P, Skakkebaek NE, Main KM. Early breast development in girls after prenatal exposure to non-persistent pesticides. Int J Androl 2012; 35: 273-282
Grandjean P, Gronlund C, Kjaer IM, Jensen TK, Sorensen N, Andersson AM, Juul A, Skakkebaek NE, Budtz-Jorgensen E, Weihe P. Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. Reprod Toxicol 2012; 34: 498-503
Bourguignon JP, Franchimont P. Puberty-related increase in episodic LHRH release from rat hypothalamus in vitro. Endocrinology 1984; 114: 1941-1943
Bourguignon JP, Gerard A, Mathieu J, Mathieu A, Franchimont P. Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D -aspartate receptors. Endocrinology 1990; 127: 873-881
Bourguignon JP, Gerard A, Alvarez Gonzalez ML, Franchimont P. Neuroendocrine mechanism of onset of puberty. Sequential reduction in activity of inhibitory and facilitatory N-methyl-D -aspartate receptors. J Clin Invest 1992; 90: 1736-1744
Parent AS, Franssen D, Fudvoye J, Gerard A, Bourguignon JP. Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: revision of human observations and mechanistic insight from rodents. Front Neuroendocrinol 2015; 38: 12-36
Lamb JC 4th, Boffetta P, Foster WG, Goodman JE, Hentz KL, Rhomberg LR, Staveley J, Swaen G, Van Der Kraak G, Williams AL. Critical comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals -2012. Regul Toxicol Pharmacol 2014; 69: 22-40
Zoeller RT, Bergman A, Becher G, Bjerregaard P, Bornman R, Brandt I, Iguchi T, Jobling S, Kidd KA, Kortenkamp A, Skakkebaek NE, Toppari K, Vandenberg LN. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health 2015; 14: 118
WHO, UNEP: State of the Science of Endocrine Disrupting Chemicals 2012. Summary for Decision-Makers. Geneva, WHO Press, 2013
Holmes D. Endocrine disruptors cause toxic fallout. Lancet Diabetes Endocrinol 2013; 21: 93-94
WHO. Global Assessment of the State-of-the-Science of Endocrine Disruptors. Geneva, WHO Press, 2002
Zoeller RT, Brown TR, Doan LL, Gore AC, Skakkebaek ME, Soto AM, Woodruff TJ, Vom Saal FS. Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology 2012; 153: 4097-4110
Kulin HE, Grumbach MM, Kaplan SL. Changing sensitivity of the pubertal gonadal hypothalamic feedback mechanism in man. Science 1969; 166: 1012-1013
Bourguignon JP, Juul A. Normal female puberty in a developmental perspective. Endocr Dev 2012; 22: 11-23
WHO. IPCS: Environmental Health Criteria 240: Principles and Methods for the Risk Assessment of Chemicals in Food. Geneva, WHO Press, 2009
Stattin H, Kerr M, Skoog T. Early pubertal timing and girls' problem behavior: integrating two hypotheses. J Youth Adolesc 2011; 40: 1271-1287
Petersen AC. Adolescent development. Annu Rev Psychol 1988; 39: 583-607
Patton GC, McMorris BJ, Toumbourou JW, Hemphill SA, Donath S, Catalano RF. Puberty and the onset of substance use and abuse. Pediatrics 2004; 114: e300-e306
Boynton-Jarrett R, Wright RJ, Putnam FW, Lividoti Hibert E, Michels KB, Forman MR, Rich-Edwards J. Childhood abuse and age at menarche. J Adolesc Health 2013; 52: 241-247
Collaborative Group on Hormonal Factors in Breast Cancer: Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118,964 women with breast cancer from 117 epidemiological studies. Lancet Oncol 2012; 13: 1141-1151
Day FR, Elks CE, Murray A, Ong KK, Perry JR. Puberty timing associated with diabetes, cardiovascular disease and also diverse health outcomes in men and women: the UK Biobank study. Sci Rep 2015; 5: 11208
DeBoer MD, Denson LA. Delays in puberty, growth, and accrual of bone mineral density in pediatric Crohn's disease: despite temporal changes in disease severity, the need for monitoring remains. J Pediatr 2013; 163: 17-22
Biro FM, Khoury P, Morrison JA. Influence of obesity on timing of puberty. Int J Androl 2006; 29: 272-277; discussion 286-290
Dunger DB, Ahmed ML, Ong KK. Early and late weight gain and the timing of puberty. Mol Cell Endocrinol 2006; 254-255: 140-145
Ong KK, Potau N, Petry CJ, Jones R, Ness AR, Honour JW, De Zegher F, Ibanez L, Dunger DB; Avon Longitudinal Study of Parents and Children Study Team: Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls. J Clin Endocrinol Metab 2004; 89: 2647-2651
Cheng G, Buyken AE, Shi L, Karaolis-Danckert N, Kroke A, Wudy SA, Degen GH, Remer T. Beyond overweight: nutrition as an important lifestyle factor influencing timing of puberty. Nutr Rev 2012; 70: 133-152
Himes JH. Examining the evidence for recent secular changes in the timing of puberty in US children in light of increases in the prevalence of obesity. Mol Cell Endocrinol 2006; 254-255: 13-21
Roa J, Tena-Sempere M. Energy balance and puberty onset: emerging role of central mTOR signaling. Trends Endocrinol Metab 2010; 21: 519-528
Ong KK, Ahmed ML, Dunger DB. Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): the European trend. Mol Cell Endocrinol 2006; 254-255: 8-12
Ibanez L, Lopez-Bermejo A, Diaz M, Marcos MV. Endocrinology and gynecology of girls and women with low birth weight. Fetal Diagn Ther 2011; 30: 243-249
Ibanez L, Jimenez R, De Zegher F. Early puberty-menarche after precocious pubarche: relation to prenatal growth. Pediatrics 2006; 117: 117-121
van Noord PA, Kaaks R. The effect of wartime conditions and the 1944-45 'Dutch famine' on recalled menarcheal age in participants of the DOM breast cancer screening project. Ann Hum Biol 1991; 18: 57-70
Tahirovic HF. Menarchal age and the stress of war: an example from Bosnia. Eur J Pediatr 1998; 157: 978-980
Moffitt TE, Caspi A, Belsky J, Silva PA. Childhood experience and the onset of menarche: a test of a sociobiological model. Child Dev 1992; 63: 47-58
Wierson M, Long PJ, Forehand RL. Toward a new understanding of early menarche: the role of environmental stress in pubertal timing. Adolescence 1993; 28: 913-924
Rasier G, Parent AS, Gerard A, Lebrethon MC, Bourguignon JP. Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane. Biol Reprod 2007; 77: 734-742
Sloboda DM, Hickey M, Hart R. Reproduction in females: the role of the early life environment. Hum Reprod Update 2011; 17: 210-227
Yoshimura S, Konno K, Ohsawa N, Noguchi S, Chisaka A. Observation of preputial separation is a useful tool for evaluating endocrine active chemicals. J Toxicol Pathol 2005; 18: 141-157
Odum J, Lefevre PA, Tinwell H, Van Miller JP, Joiner RL, Chapin RE, Wallis NT, Ashby J. Comparison of the developmental and reproductive toxicity of diethylstilbestrol administered to rats in utero, lactationally, preweaning, or postweaning. Toxicol Sci 2002; 68: 147-163
Bourguignon JP, Franssen D, Gerard A, Janssen S, Pinson A, Naveau E, Parent AS. Early neuroendocrine disruption in hypothalamus and hippocampus: developmental effects including female sexual maturation and implications for endocrine disrupting chemical screening. J Neuroendocrinol 2013; 25: 1079-1087
Matagne V, Rasier G, Lebrethon MC, Gerard A, Bourguignon JP. Estradiol stimulation of pulsatile gonadotropin-releasing hormone secretion in vitro: correlation with perinatal exposure to sex steroids and induction of sexual precocity in vivo. Endocrinology 2004; 145: 2775-2783
Franssen D, Ioannou YS, Alvarez-Real A, Gerard A, Mueller JK, Heger S, Bourguignon JP, Parent AS. Pubertal timing after neonatal diethylstilbestrol exposure in female rats: neuroendocrine vs peripheral effects and additive role of prenatal food restriction. Reprod Toxicol 2014; 44: 63-72
Rasier G, Parent AS, Gerard A, Denooz R, Lebrethon MC, Charlier C, Bourguignon JP. Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormone. Toxicol Sci 2008; 102: 33-41
Franssen D, Gerard A, Hennuy B, Parent A-S, Bourguignon JP. Disrupted neuroendocrine control of pubertal timing after early postnatal exposure to a very low dose of BPA through modulation of GABAergic neurotransmission. Abstract Book of 8th International Meeting Steroids and Nervous System, Torino 2015, pp 131-132
OECD: Detailed Review Paper on the State of the Science on Novel in vitro and in vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors. Paris, OECD, 2012
Rotroff DM, Martin MT, Dix DJ, Filer DL, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS. Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses. Environ Sci Technol 2014; 48: 8706-8716
Vandenberg LN, Maffini MV, Sonnenschein C, Rubin BS, Soto AM. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009; 30: 75-95
Rebuli ME, Cao J, Sluzas E, Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Patisaul HB. Investigation of the effects of subchronic low dose oral exposure to bisphenol A (BPA) and ethinyl estradiol (EE) on estrogen receptor expression in the juvenile and adult female rat hypothalamus. Toxicol Sci 2014; 140: 190-203
Delclos KB, Camacho L, Lewis SM, Vanlandingham MM, Latendresse JR, Olson GR, Davis KJ, Patton RE, Gamboa da Costa G, Woodling KA, Bryant MS, Chidambaram M, Trbojevich R, Juliar BE, Felton RP, Thorn BT. Toxicity evaluation of bisphenol A administered by gavage to Sprague Dawley rats from gestation day 6 through postnatal day 90. Toxicol Sci 2014; 139: 174-197
Boepple PA, Mansfield MJ, Wierman ME, Rudlin CR, Bode HH, Crigler JF Jr, Crawford JD, Crowley WF Jr. Use of a potent, long acting agonist of gonadotropin-releasing hormone in the treatment of precocious puberty. Endocr Rev 1986; 7: 24-33
Carel JC, Eugster EA, Rogol A, Ghizzoni L, et al. Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics 2009; 123: e752-e762
Wildt L, Hausler A, Marshall G, Hutchison JS, Plant TM, Belchetz PE, Knobil E. Frequency and amplitude of gonadotropin-releasing hormone stimulation and gonadotropin secretion in the rhesus monkey. Endocrinology 1981; 109: 376-385
Ross JL, Cassorla FG, Skerda MC, Valk IM, Loriaux DL, Cutler GB Jr. A preliminary study of the effect of estrogen dose on growth in Turner's syndrome. N Engl J Med 1983; 309: 1104-1106
Lampit M, Hochberg Z. Androgen therapy in constitutional delay of growth. Horm Res 2003; 59: 270-275
Tanner JM. Growth at Adolescence; With a General Consideration of the Effects of Hereditary and Environmental Factors upon Growth and Maturation from Birth to Maturity. Oxford, Blackwell Scientific, 1962
Boudon C, Lumbroso S, Lobaccaro JM, Szarras-Czapnik M, Romer TE, Garandeau P, Montoya P, Sultan C. Molecular study of the 5 alpha-reductase type 2 gene in three European families with 5 alpha-reductase deficiency. J Clin Endocrinol Metab 1995; 80: 2149-2153
Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, Jacobs DR Jr, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 2012; 33: 378-455
Ge RS, Chen GR, Dong Q, Akingbemi B, Sottas CM, Santos M, Sealfon SC, Bernard DJ, Hardy MP. Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl 2007; 28: 513-520
Saillenfait AM, Sabate JP, Gallissot F. Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat. Reprod Toxicol 2008; 26: 107-115
Rasier G, Toppari J, Parent AS, Bourguignon JP. Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data. Mol Cell Endocrinol 2006; 254-255: 187-201
Frederiksen H, Sorensen K, Mouritsen A, Aksglaede L, Hagen CP, Petersen JH, Skakkebaek NE, Andersson AM, Juul A. High urinary phthalate concentration associated with delayed pubarche in girls. Int J Androl 2012; 35: 216-226
Mouritsen A, Frederiksen H, Sorensen K, Aksglaede L, Hagen C, Skakkebaek NE, Main KM, Andersson AM, Juul A. Urinary phthalates from 168 girls and boys measured twice a year during a 5-year period: associations with adrenal androgen levels and puberty. J Clin Endocrinol Metab 2013; 98: 3755-3764