Coagulopathies in horses with colic.

Disseminated Intravascular Coagulation/complications/diagnosis/drug therapy/veterinary; Horse Diseases/blood/diagnosis/pathology; Horses; Liver Diseases/complications/pathology/veterinary

Abstract :

[en] The most common coagulopathy in horses with colic is a hypercoagulable state associated with disseminated intravascular coagulation. The intensity of this coagulopathy depends on the severity and duration of the gastrointestinal lesion, with the ischemic and inflammatory problems and peritonitis being the most frequently affected by coagulopathies. Early initiation of prophylactic therapy significantly reduces the severe hypercoagulable state in horses with intestinal conditions which are recognized to be at high risk for disseminated intravascular coagulation. In addition to the systemic coagulopathy observed in horses with colic, a peritoneal coagulopathy independent from that occurring in blood has been observed, and its recognition and assessment may have clinical usefulness in the diagnosis of the gastrointestinal diseases and outcome.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Monreal, Luis

Cesarini Latorre, Carlota ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés

Language :

English

Title :

Coagulopathies in horses with colic.

Publication date :

2009

Journal title :

Veterinary Clinics of North America. Equine Practice

ISSN :

0749-0739

eISSN :

1558-4224

Publisher :

W. B. Saunders Co., United Kingdom

Volume :

Issue :

Pages :

247-58

Available on ORBi :

since 07 April 2016

Statistics

Number of views

51 (7 by ULiège)

Number of downloads

1 (1 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Dallap B.L. Coagulopathy in the equine critical patient. Vet Clin North Am Equine Pract 20 1 (2004) 231-251
Johnstone I., and Crane S. Haemostatic abnormalities in horses with colic-their prognostic value. Equine Vet J 18 4 (1986) 271-274
Welch R., Watkins J., Taylor T., et al. Disseminated intravascular coagulation associated with colic in 23 horses (1984-1989). J Vet Intern Med 6 1 (1992) 29-35
Prasse K., Topper M., Moore J., et al. Analysis of hemostasis in horses with colic. J Am Vet Med Assoc 5 1 (1993) 685-693
Collatos C., Barton M.H., Prasse K.W., et al. Intravascular and peritoneal coagulation and fibrinolysis in horses with acute gastrointestinal tract disease. J Am Vet Med Assoc 207 4 (1995) 465-470
Monreal L., Anglés A., Espada Y., et al. Hypercoagulation and hypofibrinolysis in horses with colic and DIC. Equine Vet J 32 Suppl (2000) 19-25
Dolente B.A., Wilkins P.A., and Boston R.C. Clinicopathologic evidence of disseminated intravascular coagulation in horses with acute colitis. J Am Vet Med Assoc 220 7 (2002) 1034-1038
Yilmaz Z., Şentürk S., and İçöl Y. Analysis of hemostasis in horses with colic. Israel J Vet Med 57 2 (2002) 19-25
Dallap B.L., Dolente B., and Boston R. Coagulation profiles in 27 horses with large colon volvulus. J Vet Emerg Crit Care 13 4 (2003) 215-225
Armengou L, Monreal L, Segura D, et al. Plasma D-dimers in horses with colic. In: Proceeding of the 8th Equine Colic Research Symposium. Quebec (Canada), 2004.
Cesarini C., Monreal L., Segura D., et al. Hemostatic follow up of horses with medical and surgical colic. J Vet Intern Med 23 2 (2009) 434
Lassen E.D., and Swardson C.J. Hematology and hemostasis in the horse: normal functions and common abnormalities. Vet Clin North Am Equine Pract 11 3 (1995) 351-389
Brooks M.B. Equine coagulopathies. Vet Clin North Am Equine Pract 24 2 (2008) 335-355
Monreal L. Disseminated intravascular coagulation. In: Hinchkliff K.N., and Couëtil L. (Eds). Blackwell's five-minute veterinary consult. 2nd edition (2009), Blackwell Publishing, Oxford (UK) in press
Cotovio M., Monreal L., Navarro M., et al. Detection of fibrin deposits in tissues from horses with severe gastrointestinal disorders. J Vet Intern Med 21 2 (2007) 308-313
Delgado M.A., Monreal L., Armengou L., et al. Peritoneal D-dimer concentration for assessing peritoneal fibrinolytic activity in horses with colic. J Vet Intern Med 23 (2009) in press
Morris D.D., Vaala W.E., and Sartin E. Protein-losing enteropathy in a yearling filly with subclinical disseminated intravascular coagulation and autoimmune hemolytic disease. Comp Cont Educ Pract Vet 4 12 (1982) 542-546
Pablo L., Purohit R., Teer P., et al. Disseminated intravascular coagulation in experimental intestinal strangulation obstruction in ponies. Am J Vet Res 44 11 (1983) 2115-2122
Dolente B.A., Beech J., Lindborg S., et al. Evaluation of risk factors for the development of catheter-associated jugular thrombophlebitis in horses: 50 cases (1993-1998). J Am Vet Med Assoc 227 7 (2005) 1134-1141
Divers T.J. Prevention and treatment of thrombosis, phlebitis, and laminitis in horses with gastrointestinal diseases. Vet Clin North Am Equine Pract 19 3 (2003) 779-790
Cotovio M., Monreal L., Navarro M., et al. Detection of fibrin deposits in horse tissues by immunohistochemistry. J Vet Intern Med 21 5 (2007) 1083-1089
Norman T.E., Chaffin M.K., Perris E.E., et al. Massive pulmonary thromboembolism in six horses. Equine Vet J 40 5 (2008) 514-517
Segura D., Monreal L., Armengou L., et al. Mean platelet component as an indicator of platelet activation in foals and adult horses. J Vet Intern Med 21 5 (2007) 1076-1082
Topper M., and Prasse K. Use of enzyme-linked immunosorbent assay to measure thrombin-antithrombin III complexes in horses with colic. Am J Vet Res 57 4 (1996) 456-462
Feige K., Kästner S.B.R., Dempfle C.E., et al. Changes in coagulation and markers of fibrinolysis in horses undergoing colic surgery. J Vet Med A Physiol Pathol Clin Med 50 1 (2003) 30-36
Topper M.J., and Prasse K.W. Analysis of coagulation proteins as acute-phase reactants in horses with colic. Am J Vet Res 59 5 (1998) 542-545
Holland M., Kelly A., Snyder J., et al. Antithrombin III activity in horses with large colon torsion. Am J Vet Res 47 4 (1986) 897-900
Collatos C., Barton M.H., Schleef R., et al. Regulation of equine fibrinolysis in blood and peritoneal fluid based on a study of colic cases and induced endotoxaemia. Equine Vet J 26 6 (1994) 474-481
Collatos C., Barton M.H., and Moore J.N. Fibrinolytic activity in plasma from horses with gastrointestinal diseases: Changes associated with diagnosis, surgery, and outcome. J Vet Intern Med 9 1 (1995) 18-23
Stokol T., Erb H.N., De Wilde L., et al. Evaluation of latex agglutination kits for detection of fibrin(ogen) degradation products and D-dimer in healthy horses and horses with severe colic. Vet Clin Pathol 3 4 (2005) 375-382
Sandholm M., Vidovic A., Puotunen-Reinert A., et al. D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic. Acta Vet Scand 36 2 (1995) 255-272
Monreal L. Treating disseminated intravascular coagulation. Comp Cont Educ Vet Equine 3 6 (2008) 326-330
Monreal L., and Aguilera E. Management of horses with coagulopathies. In: Corley K., and Stephen J. (Eds). The equine hospital manual (2008), Blackwell Publishing, Oxford (UK) 409-416
Monreal L., Villatoro A.J., Monreal M., et al. Comparison of the effects of low-molecular-weight and unfractioned heparin in horses. Am J Vet Res 56 10 (1995) 1281-1285
Feige K., Schwarzwald C.C., and Bombeli T. Comparison of unfractioned and low molecular weight heparin for prophylaxis of coagulopathies in 52 horses with colic: a randomised double-blind clinical trial. Equine Vet J 35 5 (2003) 506-513
diZerega G.S., and Campeau J.D. Peritoneal repair and post-surgical adhesion formation. Hum Reprod Uptake 7 6 (2001) 547-555
Cheong Y.C., Laird S.M., Li T.C., et al. Peritoneal healing and adhesion formation/reformation. Hum Reprod Uptake 7 6 (2001) 556-566
Delgado MA, Monreal L, Tarancón I, et al. Effects of blood contamination on peritoneal D-dimer concentration in horses with colic. In: Proceedings of the 9th International Equine Colic Research Symposium. Liverpool (UK), 2008.
Monreal L. Monitoring the coagulation system. In: Corley K., and Stephen J. (Eds). The equine hospital manual (2008), Blackwell Publishing, Oxford (UK) 401-409
Turner T.A., Brown C.A., Wilson J.H., et al. Hepatic lobe torsion as a cause of colic in a horse. Vet Surg 22 4 (1993) 301-304
Durando M.M., MacKay R.J., Staller G.S., et al. Septic cholangiohepatitis and cholangiocarcinoma in a horse. J Am Vet Med Assoc 206 7 (1995) 1018-1021
Ryu S.H., Bak U.B., Lee C.W., et al. Cholelithiasis associated with recurrent colic in a thoroughbred mare. J Vet Sci 5 1 (2004) 79-82
Durham A. Monitoring and treating the liver. In: Corley K., and Stephen J. (Eds). The equine hospital manual (2008), Blackwell Publishing, Oxford (UK) 520-532
Vachon A.M., and Fisher A.T. Small intestinal herniation through the epiploic foramen: 53 cases (1987-1993). Equine Vet J 27 5 (1995) 373-380
Davis J.L., Blikslager A.T., Catto K., et al. A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002). J Vet Intern Med 17 6 (2003) 896-901
Lisman T., Leebeek F.W.G., and de Groot P.G. Haemostatic abnormalities in patients with liver disease. J Hepatol 37 2 (2002) 280-287
Tripodi A., and Manucci P.M. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol 46 4 (2007) 727-733
Johns I.C., and Sweeney R.W. Coagulation abnormalities and complications after percutaneous liver biopsy in horses. J Vet Intern Med 22 1 (2008) 185-189