Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke

[en] Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. The later finding seems to be caused by difficulties regarding the chunking of operant actions into a coherent motor sequence; the appeal for food rewards and ability to press levers appeared unaffected by MCAO. We conclude that assessment of motor learning in rodent models of stroke might improve the translational value of such models.

Disciplines :

Neurosciences & behavior

Author, co-author :

Linden, Jérôme ; Université de Liège > Département de Psychologie > Psychologie de l'apprentissage et cognition animale

Van de Beek, Lise; Université de Liège - ULiège > Département de Psychologie > Psychologie de l'Apprentissage et de la Cognition Animale

Plumier, Jean-Christophe ; Université de Liège > Département de Biologie, Ecologie et Evolution > Ecophysiologie et physiologie animale

Ferrara, André ; Université de Liège > Département de Psychologie > Psychologie de l'apprentissage et cognition animale

Language :

English

Title :

Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke

Publication date :

18 March 2016

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

307

Pages :

35-45

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.ncbi.nlm.nih.gov/pubmed/27001455

Available on ORBi :

since 05 April 2016

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