Serotonergic modulation of the P300 event related brain potential

While dopaminergic, noradrenergic, cholinergic and gabaergic effects on the P300 component of the human event-related brain potential have been largely described, little is known about serotonergic influence. Therefore, we investigated the relationship between P300 and serotonergic activity as reflected by prolactin (PRL) response to flesinoxan, a 5-HT1A full agonist, among 28 normal subjects. Results showed a significant negative correlation between P300 amplitude and PRL response to flesinoxan (r = -0.47, p = 0.01 at Cz; r = -0.45, p = 0.01 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin in the neurobiological modulation of P300 amplitude. Clinical implications of these results are considered.

Disciplines :

Psychiatry
Treatment & clinical psychology

Author, co-author :

Hansenne, Michel ; Université de Liège - ULiège > Département de Psychologie > Psycho. de la personnalité et des différences individuelles

PITCHOT, William ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de psychiatrie

Papart, Patrick ; Université de Liège - ULiège > Département des sciences cliniques > Psycho. quantitative - Psychiatrie légale et sociale

ANSSEAU, Marc ; Université de Liège - ULg

Language :

English

Title :

Serotonergic modulation of the P300 event related brain potential

Publication date :

1998

Journal title :

Human Psychopharmacology

ISSN :

0885-6222

eISSN :

1099-1077

Publisher :

John Wiley & Sons, Hoboken, United States - New Jersey

Volume :

Issue :

Pages :

239-243

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 July 2021

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