Article (Scientific journals)
COMMENT JE TRAITE ... Point de vue critique sur l'approche actuelle du cancer du pancreas localisé
VAN DAELE, Daniel; Martinive, Philippe; LOLY, Catherine et al.
2015In Revue Médicale de Liège, 70 (11), p. 540-5
Peer reviewed
 

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Keywords :
Adenocarcinoma/mortality/therapy; Antineoplastic Agents/therapeutic use; Carcinoma, Pancreatic Ductal/mortality/therapy; Humans; Neoadjuvant Therapy; Pancreatectomy; Pancreatic Neoplasms/mortality/therapy; Patient Selection; Prognosis
Abstract :
[en] Surgical resection followed by chemotherapy is the actual standard of care for localized, deemed resectable, pancreatic ductal adenocarcinoma. Despite a better selection of surgical candidates and the actual performance of expert teams, the proportion of patients with a prolonged survival has not been ameliorated during the last three decades. The morphological determinants of resectability are the subject of limitations. In the future, only a better understanding of the biological process, an earlier diagnosis of purely localized disease and more efficient systemic therapies may lead to a better prognosis. Meanwhile, taking into account the prognostic factors associated with a lower chance of cure is currently a matter of debate. The optimal therapeutic sequence, being a surgery-first or a neoadjuvant approach is controversial. The theoretical advantages of preoperative chemotherapy eventually associated with chemo-radiation are demonstrated in other tumours and applicable to pancreatic cancer without any excess of operative mortality, early progression rates and, on the contrary with positive survival data. The completion rates of multi-modal therapy are in favour of the preoperative approach, which also gives the opportunity to select the best candidates for surgical resection.
Disciplines :
Oncology
Author, co-author :
VAN DAELE, Daniel ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Martinive, Philippe ;  Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
LOLY, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
POLUS, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Service de gastroentérologie, hépatologie, onco. digestive
COLLIGNON, Joëlle  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
GAST, Pierrette ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive
Louis, Edouard  ;  Université de Liège > Département des sciences cliniques > Hépato-gastroentérologie
Van Laethem, J.-L.;  Hôpital Erasme
Language :
French
Title :
COMMENT JE TRAITE ... Point de vue critique sur l'approche actuelle du cancer du pancreas localisé
Alternative titles :
[en] CRITICAL VIEWPOINT ON THE CURRENT APPROACH OF LOCALIZED PANCREATIC DUCTAL ADENOCARCINOMA
Publication date :
2015
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
70
Issue :
11
Pages :
540-5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 08 March 2016

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