Drug Resistance, Bacterial/genetics; Macrolides; Multicenter Studies as Topic; Phenotype; Streptococcal Infections/drug therapy/genetics/microbiology; Streptococcus pyogenes/drug effects/genetics/isolation & purification
Abstract :
[en] Five hundred and seventy-eight strains of group A streptococci (GAS) isolated mostly from paediatric pharyngeal swabs were tested to evaluate their susceptibility to erythromycin. Resistant strains were then tested for their MICs to erythromycin and clindamycin, their phenotype of resistance to macrolides-lincosamides-streptogramin (MLS(B)) and for the presence of macrolide resistance genes. The rate of resistance to erythromycin was 8.2%. Constitutive, inducible and M phenotypes of resistance were detected in 2.1, 2.1 and 95.8% of resistant strains, respectively. All M phenotypes harboured the mefA gene, whereas constitutive and inducible phenotypes had ermB and ermTR genes, respectively.
Disciplines :
Microbiology
Author, co-author :
Martinez, Silvia
Amoroso, Ana Maria ; Université de Liège > Département des sciences de la vie > Centre d'ingénierie des protéines
Famiglietti, Angela
de Mier, Carmen
Vay, Carlos
Gutkind, Gabriel O.
Language :
English
Title :
Genetic and phenotypic characterization of resistance to macrolides in Streptococcus pyogenes from Argentina.
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