Article (Scientific journals)
Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma
Grégoire, Céline; GUIOT, Julien; Vertenoeil, Gaëlle et al.
2016In Acta Clinica Belgica, 71, p. 428-430
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Keywords :
Yellow nail syndrome; Allogeneic haematopoietic cell transplantation; Graft-versus-host-disease; Multiple myeloma
Abstract :
[en] Objective and Importance: Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory. Clinical Presentation: We report for the first time two cases of YNS associated with multiple myeloma relapsing after non-myeloablative haematopoietic cell transplantation (HCT). In these two cases, onset or worsening of YNS symptoms followed graft-versus-host disease (GvHD) manifestations. Intervention: Corticosteroids given to treat GvHD also improved YNS manifestations. Conclusion: YNS after HCT might be a microvascular manifestation of endothelial GvHD and corticosteroids might be an effective treatment.
Disciplines :
Hematology
Author, co-author :
Grégoire, Céline  ;  Université de Liège > GIGA-R : Hématologie
GUIOT, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Vertenoeil, Gaëlle ;  Université de Liège > GIGA-R : Hématologie
WILLEMS, Evelyne ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
HAFRAOUI, Kaoutar ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
CORHAY, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
LOUIS, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
BEGUIN, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Yellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma
Publication date :
February 2016
Journal title :
Acta Clinica Belgica
ISSN :
0001-5512
Publisher :
Acta Clinica Belgica, Bruxelles, Belgium
Volume :
71
Pages :
428-430
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
IF = 0.622
Available on ORBi :
since 27 February 2016

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