Article (Scientific journals)
Management of relapsed multiple myeloma: Recommendations of the international myeloma working group
Laubach, J.; Garderet, L.; Mahindra, A. et al.
2016In Leukemia, 30 (5), p. 1005-1017
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Abstract :
[en] The prognosis for patients multiple myeloma (MM) has improved substantially over the past decade with the development of new, more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity. In spite of this important progress, however, nearly all MM patients ultimately relapse, even those who experience a complete response to initial therapy. Management of relapsed MM thus represents a vital aspect of the overall care for patients with MM and a critical area of ongoing scientific and clinical research. This comprehensive manuscript from the International Myeloma Working Group provides detailed recommendations on management of relapsed disease, with sections dedicated to diagnostic evaluation, determinants of therapy, and general approach to patients with specific disease characteristics. In addition, the manuscript provides a summary of evidence from clinical trials that have significantly impacted the field, including those evaluating conventional dose therapies, as well as both autologous and allogeneic stem cell transplantation. Specific recommendations are offered for management of first and second relapse, relapsed and refractory disease, and both autologous and allogeneic transplant. Finally, perspective is provided regarding new agents and promising directions in management of relapsed MM.
Disciplines :
Hematology
Author, co-author :
Laubach, J.
Garderet, L.
Mahindra, A.
Gahrton, G.
CAERS, Jo  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Sezer, O.
Voorhees, P.
Leleu, X.
Johnsen, HE.
Streetly, M.
Ludwig, H.
Mellqvist, UH.
Chng, WJ.
Pilarski, L.
Einsele, H.
Hou, J.
Turesson, I.
Zamagni, E.
Chim, J.
Mazumder, A.
Westin, J.
Lu, J.
Reiman, T.
Kristinsson, S.
Joshua, D.
Roussel, M.
O'Gorman, P.
Terpos, E.
Dimopoulos, M.
Moreau, P.
Anderson, K.
Palumbo, A.
Kumar, S.
Rajkumar, V.
Durie, B.
Richardson, P.
More authors (26 more) Less
Language :
English
Title :
Management of relapsed multiple myeloma: Recommendations of the international myeloma working group
Publication date :
30 May 2016
Journal title :
Leukemia
ISSN :
0887-6924
eISSN :
1476-5551
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
30
Issue :
5
Pages :
1005-1017
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2016

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