Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sahebkar, A; Henrotin, Yves

doi:10.1093/pm/pnv024

Article (Scientific journals)

Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Sahebkar, A; Henrotin, Yves

2016 • In Pain Medicine

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/192521

DOI
10.1093/pm/pnv024

PubMed
26814259

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Abstract :

[en] Background. Curcuminoids are natural products with potent anti-inflammatory and antioxidant properties. There have been a number of reports on the analgesic effects of curcuminoids in clinical trials, yet data have not been fully conclusive. Objectives. To provide the highest level of evidence on the efficacy of curcuminoids in patients with painful conditions through meta-analysis of data from randomized controlled trials (RCTs). Methods. A systematic review and meta-analysis was conducted using data reported by RCTs. The primary efficacy measure was pain intensity or algofunctional status. Treatment effect was summarized with standardized mean difference (SMD) calculated from differences in means of pain measures between treatment and control groups using a random-effects model. Results. A total of eight RCTs met our inclusion criteria that included 606 randomized patients. Curcuminoids were found to significantly reduce pain (SMD: −0.57, 95% CI: −1.11 to −0.03, P = 0.04). This pain-relieving effect was found to be independent of administered dose and duration of treatment with curcuminoids, and was free from publication bias. Curcuminoids were safe and well tolerated in all evaluated RCTs. Conclusion. Curcuminoids supplements may be a safe and effective strategy to improve pain severity, by warranting further rigorously conducted studies to define the long-term efficacy and safety.

Disciplines :

Rheumatology

Author, co-author :

Sahebkar, A

Henrotin, Yves ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Language :

English

Title :

Analgesic Efficacy and Safety of Curcuminoids in Clinical Practice: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Publication date :

2016

Journal title :

Pain Medicine

ISSN :

1526-2375

eISSN :

1526-4637

Publisher :

Blackwell Publishing

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://painmedicine.oxfordjournals.org/content/early/2015/12/12/pm.pnv024

Available on ORBi :

since 28 January 2016

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151

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OpenCitations

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121

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