Effects of Sodium Naproxen on Differentiated Human Chondrocytes Cultivated in Clusters

[en] The effects of different pharmacological concentrations of the non-steroidal anti-inflammatory drug (NSAID) sodium naproxen (NAP) were tested on several metabolic functions of differentiated human chondrocytes cultivated in clusters and compared with the action of acetylsalicylic acid (ASA). DNA synthesis was significantly inhibited by ASA but not by NAP. Proteoglycan production was also markedly decreased by ASA, while synthesis of type II collagen was not modified. By contrast, NAP did not affect these chondroformative processes. Both NSAIDs were potent inhibitors of prostaglandin E2 production. These results indicate that in terms of the parameters tested NAP does not lead to deleterious effects on human articular chondrocytes cultured in vitro.

Disciplines :

Rheumatology

Author, co-author :

Bassleer, C.

Henrotin, Yves ; Université de Liège - ULiège > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Franchimont, P.

Language :

English

Title :

Effects of Sodium Naproxen on Differentiated Human Chondrocytes Cultivated in Clusters

Publication date :

March 1992

Journal title :

Clinical Rheumatology

ISSN :

0770-3198

eISSN :

1434-9949

Publisher :

Springer, Germany

Volume :

Issue :

Pages :

60-5

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 January 2016

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