[en] OBJECTIVE: To investigate the association between urinary biomarker Coll2-1NO2 (uColl2-1NO2) and incident knee OA after 2.5 years follow-up in middle-aged overweight and obese women at high risk for knee osteoarthritis (OA). DESIGN: Data were used from PROOF, a randomized controlled trial with 2.5 years follow-up evaluating the preventive effects of a diet and exercise program and oral glucosamine sulphate (double blind and placebo controlled), on development of incident knee OA in women with body mass index >/= 27 kg/m(2) without signs of knee OA at baseline. Baseline and 2.5 years uColl2-1NO2 concentrations were assessed with enzyme-linked immunosorbent assay (ELISA). Primary outcome measure was incidence of knee OA in one or both knees, defined as incidence of either Kellgren & Lawrence grade >/=2, joint space narrowing of >/=1.0 mm or knee OA according to the combined clinical and radiographic ACR-criteria. We used binary logistic regression for the association analyses. RESULTS: 254 women were available for analyses. At 2.5 years follow-up, incident knee OA was present in 72 of 254 women (28.3%). An inversed association was found between baseline uColl2-1NO2 and incident knee OA at 2.5 years (OR 0.74, 95% CI 0.55-0.99). The concentration at 2.5 years and the change in concentration over 2.5 years did not show significant associations with the outcome. CONCLUSIONS: In overweight and obese middle-aged women, not higher but lower baseline uColl2-1NO2 concentration was significantly associated with an increased risk for incident knee OA. This interesting but counterintuitive outcome makes further validation of this biomarker warranted.
Disciplines :
Rheumatology
Author, co-author :
Landsmeer, M. L.
Runhaar, J.
Henrotin, Yves ; Université de Liège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)
Middelkoop van, M.
Oei, E. H.
Vroegindeweij, D.
Reijman, M.
van Osch, G. J.
Koes, B. W.
Bindels, P. J.
Bierma-Zeinstra, Sita M. A.
Language :
English
Title :
Association of urinary biomarker COLL2-1NO2 with incident clinical and radiographic knee OA in overweight and obese women
Wright R.W., Boyce R.H., Michener T., Shyr Y., McCarty E.C., Spindler K.P. Radiographs are not useful in detecting arthroscopically confirmed mild chondral damage. Clin Orthop Relat Res 2006, 442:245-251.
Schiphof D., Oei E.H., Hofman A., Waarsing J.H., Weinans H., Bierma-Zeinstra S.M. Sensitivity and associations with pain and body weight of an MRI definition of knee osteoarthritis compared with radiographic Kellgren and Lawrence criteria: a population-based study in middle-aged females. Osteoarthritis Cartilage 2014, 22:440-446.
van Spil W.E., DeGroot J., Lems W.F., Oostveen J.C., Lafeber F.P. Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria. Osteoarthritis Cartilage 2010, 18:605-612.
Henrotin Y., Deberg M., Dubuc J.E., Quettier E., Christgau S., Reginster J.Y. Type II collagen peptides for measuring cartilage degradation. Biorheology 2004, 41:543-547.
Henrotin Y.E., Bruckner P., Pujol J.P. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthritis Cartilage 2003, 11:747-755.
Sokolove J., Lepus C.M. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis 2013, 5:77-94.
Runhaar J., van Middelkoop M., Reijman M., Willemsen S., Oei E.H., Vroegindeweij D., et al. Prevention of knee osteoarthritis in overweight females; the first preventive randomized controlled trial in osteoarthritis. Am J Med 2015, [Epub ahead of print].
Blagojevic M., Jinks C., Jeffery A., Jordan K.P. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage 2010, 18:24-33.
Reijman M., Pols H.A., Bergink A.P., Hazes J.M., Belo J.N., Lievense A.M., et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 2007, 66:158-162.
Altman R., Asch E., Bloch D., Bole G., Borenstein D., Brandt K., et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986, 29:1039-1049.
Buckland-Wright J.C., Wolfe F., Ward R.J., Flowers N., Hayne C. Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and schuss views. JRheumatol 1999, 26:2664-2674.
Kellgren J.H., Lawrence J.S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957, 16:494-502.
Lequesne M. Quantitative measurements of joint space during progression of osteoarthritis: chondrometry. Osteoarthritic Disorders 1995, 427-444. American Academy of Orthopaedic Surgeons, Rosemont. K. Kuettner, V. Goldberg (Eds.).
Runhaar J., van Middelkoop M., Reijman M., Vroegindeweij D., Oei E.H., Bierma-Zeinstra S.M. Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women. Rheumatology (Oxford) 2014, 53:1618-1624.
Brouwer G.M., van Tol A.W., Bergink A.P., Belo J.N., Bernsen R.M., Reijman M., et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum 2007, 56:1204-1211.
Deberg M.A., Labasse A.H., Collette J., Seidel L., Reginster J.Y., Henrotin Y.E. One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression. Osteoarthritis Cartilage 2005, 13:1059-1065.
Deberg M., Labasse A., Christgau S., Cloos P., Bang Henriksen D., Chapelle J.P., et al. New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage 2005, 13:258-265.
Rosenquist C., Fledelius C., Christgau S., Pedersen B.J., Bonde M., Qvist P., et al. Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Clin Chem 1998, 44:2281-2289.
Jaffé M. Über den Niederschlag, welchen Picrinsäure in normalem Harn erzeugt und über eine neue Reaktion des Kreatinins. Hoppe-Seyler's Z. Physiol Chem 1886, 10:8.
Wendel-Vos G.C., Schuit A.J., Saris W.H., Kromhout D. Reproducibility and relative validity of the short questionnaire to assess health-enhancing physical activity. JClin Epidemiol 2003, 56:1163-1169.
Runhaar J. Development and Prevention of Knee Osteoarthritis; the Load of Obesity 2013, 193. Department of General Practice, Erasmus University Rotterdam, Rotterdam.
Bierma-Zeinstra S.M., Koes B.W. Risk factors and prognostic factors of hip and knee osteoarthritis. Nat Clin Pract Rheumatol 2007, 3:78-85.
John T., Muller R.D., Oberholzer A., Zreiqat H., Kohl B., Ertel W., et al. Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes invitro. Cytokine 2007, 40:226-234.
Schulze-Tanzil G. Activation and dedifferentiation of chondrocytes: implications in cartilage injury and repair. Ann Anat 2009, 191:325-338.
Wang Y., Lou S. Direct protective effect of interleukin-10 on articular chondrocytes invitro. Chin Med J (Engl) 2001, 114:723-725.
Mabey T., Honsawek S. Cytokines as biochemical markers for knee osteoarthritis. World J Orthop 2015, 6:95-105.
Wojdasiewicz P., Poniatowski L.A., Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediat Inflamm 2014, 2014:561459.
Stannus O.P., Jones G., Blizzard L., Cicuttini F.M., Ding C. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann Rheum Dis 2013, 72:535-540.
Sellam J., Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010, 6:625-635.
Sowers M.R., Karvonen-Gutierrez C.A. The evolving role of obesity in knee osteoarthritis. Curr Opin Rheumatol 2010, 22:533-537.
Reis C., Viana Queiroz M. Prevalence of self-reported rheumatic diseases in a portuguese population. Acta Reumatol Port 2014, 39:54-59.
Palazzo C., Ravaud J.F., Papelard A., Ravaud P., Poiraudeau S. The burden of musculoskeletal conditions. PLoS One 2014, 9:e90633.
Knight M., Stewart-Brown S., Fletcher L. Estimating health needs: the impact of a checklist of conditions and quality of life measurement on health information derived from community surveys. JPublic Health Med 2001, 23:179-186.