Article (Scientific journals)
N-Hydroxy-6-(5-Nitro- Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth
Shiva Shankar, Thammadihalli Veerasangaiah; Sulka, B.; Hubert, Pascale et al.
2015In Journal of Cancer Sciences, 2 (2), p. 0-11
Peer reviewed
 

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Keywords :
Lysine acetylation; Cytosine methylation; Angiogenesis inhibitor
Abstract :
[en] In this report, we present a novel histone deacetylase inhibitor (HDACi) (N-Hydroxy-6-(5-nitro-naphtalimide)-hexanamide: ES8) that efficiently inhibits angiogenesis in relevant ex vivo models (Human umbilical vein endothelial cells (HUVEC), 3D aortic ring assay) and in vivo (chick chorioallantoic membrane (CAM), Zebrafish). Transcriptomic profiling reveals a set of ES8 specific genes that are not affected by the prototypical HDACi suberoylanilide hydroxamic acid (SAHA). Finally, ES8 also reduced tumor growth in mouse models of small cell lung cancer. Availability of a novel compound not centered exclusively on inhibition of angiogenic factors and inducing a characteristic transcription profile may be of interest to overcome resistance to currently used chemotherapies.
Disciplines :
Oncology
Author, co-author :
Shiva Shankar, Thammadihalli Veerasangaiah ;  Université de Liège - ULiège > GIGA - Membres
Sulka, B.
Hubert, Pascale  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Hubaux, R.
Delvenne, Philippe 
Pendeville-Samain, Hélène ;  Université de Liège > GIGA-Research
Boittiaux, Irving
Lambert, Didier M.
Wouters, Johan
Maillard, C.
Blacher, Silvia ;  Centre Hospitalier Universitaire de Liège - CHU
Noël, Agnès ;  Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Struman, Ingrid  ;  Université de Liège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Willems, Luc  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
More authors (4 more) Less
Language :
English
Title :
N-Hydroxy-6-(5-Nitro- Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth
Publication date :
2015
Journal title :
Journal of Cancer Sciences
eISSN :
2377-9292
Publisher :
Avens Publishers
Volume :
2
Issue :
2
Pages :
0-11
Peer reviewed :
Peer reviewed
Name of the research project :
Sixth Research Framework Programme of the European Union (project INCA LSHC-CT-2005-018704)
BELVIR Inter university Attraction Poles Program 7/45 initiated by the Belgian Science Policy Office
Action de Recherche Concertée "Glyvir” of the Communauté française de Belgique
The “Neoangio” excellence program
Agricultureislife
Synbiofor
The “Plan Cancer” of the Service Public Fédéral
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Télévie [BE]
Belgian Foundation Against Cancer [BE]
SPW DGO6 - Service Public de Wallonie. Economie, Emploi, Recherche [BE]
CFB - Communauté française de Belgique [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
ULg FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
BELSPO - Belgian Science Policy Office [BE]
Funding text :
The “Partenariat Public Privé” PPP INCA of the “Direction générale des Technologies, de la Recherche et de l’Energie/DG06” of the Walloon government
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since 13 January 2016

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