Penicillin-binding proteins: evergreen drug targets.

Anti-Bacterial Agents/pharmacology; Penicillin Resistance/physiology; Penicillin-Binding Proteins/antagonists & inhibitors/chemistry/metabolism; Protein Conformation; beta-Lactams/pharmacology

Abstract :

[en] The penicillin-binding proteins (PBPs) are well known targets for the beta-lactam antibiotics. They continue to be a focus of interest for pharmaceutical design, as exemplified by the number of new agents under clinical investigation as well as novel experimental molecules. Considerable advances have been made in understanding the structure and function of this family of enzymes, through high-resolution structural studies and mechanistic studies in solution. These studies have thrown light on role of the high molecular mass PBPs in mediating beta-lactam resistance, although much work remains to be done to enable a full description of the mechanisms by which these proteins modulate their sensitivity towards beta-lactams while retaining their essential activity in cell wall biosynthesis.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Frère, Jean-Marie ; Université de Liège - ULiège

Page, Malcolm G. P.

Language :

English

Title :

Penicillin-binding proteins: evergreen drug targets.

Publication date :

2014

Journal title :

Current Opinion in Pharmacology

ISSN :

1471-4892

eISSN :

1471-4973

Publisher :

Elsevier, Netherlands

Volume :

Pages :

112-9

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 22 December 2015

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