Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

Bacillus cereus/enzymology; Bacterial Proteins; Binding Sites; Combinatorial Chemistry Techniques; Cysteine; Dipeptides/chemical synthesis/pharmacology; Enzyme Inhibitors/pharmacology; Hydrogen-Ion Concentration; Kinetics; Structure-Activity Relationship; Zinc; beta-Lactamase Inhibitors; beta-Lactamases/chemistry

Abstract :

[en] Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-beta-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). D,D-Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Bounaga, S.

Galleni, Moreno ; Université de Liège - ULiège

Laws, A. P.

Page, M. I.

Language :

English

Title :

Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase.

Publication date :

2001

Journal title :

Bioorganic and Medicinal Chemistry

ISSN :

0968-0896

eISSN :

1464-3391

Publisher :

Elsevier, United Kingdom

Volume :

Issue :

Pages :

503-10

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 December 2015

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