The supercritical micronization of solid dispersions by Particles from Gas Saturated Solutions using experimental design

The Particle from Gas Saturated Solutions process was successfully used to micronize solid
dispersions containing hydrophilic carriers and a new chemical entity, YNS3107. By means
of experimental design, the effects of several experimental parameters on micronization were
investigated. Within the chosen experimental conditions, the results showed that the autoclave
temperature, autoclave pressure, drug loading, flow rate of carbon dioxide and air pressure
were significant parameters. During the optimization step, the most relevant parameters of the
screening were optimized using a central composite design meanwhile other factors were kept
constant. Optimal conditions were used to produce microparticles with a volume weighted
mean diameter of 30.4 µm. The closeness between the measured and predicted response,
evaluated at 28.1 µm, demonstrated the validity of the statistical analyses. Finally, an
enhancement of the rate of dissolution of YNS3107 in the solid dispersion microparticles was
measured using USP II dissolution test apparatus.