Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss.

Adult; Arousal/genetics/physiology; Attention/physiology; Brain/physiopathology; Brain Stem/physiopathology; Circadian Rhythm/genetics/physiology; Female; Functional Neuroimaging; Gyrus Cinguli/physiopathology; Humans; Magnetic Resonance Imaging; Male; Neural Pathways/physiopathology; Period Circadian Proteins/genetics; Polymorphism, Genetic; Prefrontal Cortex/physiopathology; Psychomotor Performance/physiology; Reaction Time/genetics/physiology; Sleep Deprivation/genetics/physiopathology/psychology; Thalamus/physiopathology; Young Adult

Abstract :

[en] OBJECTIVE: Even though wakefulness at night leads to profound performance deterioration and is regularly experienced by shift workers, its cerebral correlates remain virtually unexplored. METHODS: We assessed brain activity in young healthy adults during a vigilant attention task under high and low sleep pressure during night-time, coinciding with strongest circadian sleep drive. We examined sleep-loss-related attentional vulnerability by considering a PERIOD3 polymorphism presumably impacting on sleep homeostasis. RESULTS: Our results link higher sleep-loss-related attentional vulnerability to cortical and subcortical deactivation patterns during slow reaction times (i.e., suboptimal vigilant attention). Concomitantly, thalamic regions were progressively less recruited with time-on-task and functionally less connected to task-related and arousal-promoting brain regions in those volunteers showing higher attentional instability in their behavior. The data further suggest that the latter is linked to shifts into a task-inactive default-mode network in between task-relevant stimulus occurrence. INTERPRETATION: We provide a multifaceted view on cerebral correlates of sleep loss at night and propose that genetic predisposition entails differential cerebral coping mechanisms, potentially compromising adequate performance during night work.

Disciplines :

Neurosciences & behavior

Author, co-author :

Maire, Micheline

Reichert, Carolin Franziska

Gabel, Virginie

Viola, Antoine U.

Phillips, Christophe ; Université de Liège > Centre de recherches du cyclotron

Krebs, Julia

Scheffler, Klaus

Klarhofer, Markus

Strobel, Werner

Cajochen, Christian

Schmidt, Christina ; Université de Liège > Département de Psychologie : cognition et comportement > Neuropsychologie

Language :

English

Title :

Fighting Sleep at Night: Brain Correlates and Vulnerability to Sleep Loss.

Publication date :

2015

Journal title :

Annals of Neurology

ISSN :

0364-5134

eISSN :

1531-8249

Publisher :

John Wiley & Sons, Hoboken, United States - New York

Volume :

Issue :

Pages :

235-47

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 26 October 2015

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