[en] A novel and facile one-pot copolymerization approach was developed for the preparation of a beta-cyclodextrin (beta-CD) functionalized organic polymer monolith. The proposed one-pot process involved two major reactions occurring in sequence in the same vial: (1) the ring opening reaction between the epoxy groups of glycidyl methacrylate (GMA) and the primary amino groups of ethylenediamine-beta-CD (EDA-beta-CD); (2) the copolymerization of glycidyl methacrylate-ethylenediamine-beta-CD (GMA-EDA-beta-CD) and ethylene dimethacrylate (EDMA) using 2,2'-azobisisobutyronitrile (AIBN) as the polymerization initiator. This approach avoids the time-consuming post-polymerization derivatization of the traditional two-step strategy. Compared to the previously reported two-step strategy, the monolith prepared by this one-pot method exhibited higher beta-CD ligand density and better column efficiency in HPLC. Satisfactory column permeability and separation selectivity were also obtained on the optimized poly(GMA-EDA-beta-CD-co-EDMA) monolithic column. Additionally, the column was also applied to the enantioseparation of some racemic acidic compounds with promising results.
Research Center/Unit :
Centre Interfacultaire de Recherche du Médicament - CIRM
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Zhang, Qiaoxuan
Guo, Jialiang
Wang, Feng
Crommen, Jacques ; Université de Liège > Département de pharmacie > Département de pharmacie
Jiang, Zhengjin
Language :
English
Title :
Preparation of a beta-cyclodextrin functionalized monolith via a novel and simple one-pot approach and application to enantioseparations.
Publication date :
2014
Journal title :
Journal of Chromatography. A
ISSN :
0021-9673
eISSN :
1873-3778
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
1325
Pages :
147-54
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
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