Reference : Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells.
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/186924
Biological Effects of Cardiac Magnetic Resonance on Human Blood Cells.
English
LANCELLOTTI, Patrizio mailto [Centre Hospitalier Universitaire de Liège - CHU > > Cardiologie >]
NCHIMI LONGANG, Alain mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic >]
Delierneux, Céline mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Hego, Alexandre mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Gosset, Christiane mailto [Université de Liège > Département des sciences de la santé publique > Santé publique : aspects généraux >]
Gothot, André mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la coagulation et de l'hémostase >]
TSHIBANDA, Luaba mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiodiagnostic >]
Oury, Cécile mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
2015
Circulation: Cardiovascular Imaging
8
9
Yes (verified by ORBi)
International
1941-9651
1942-0080
United States
[en] DNA damage ; blood cells ; cell death ; flow cytometry ; lymphocytes
[en] BACKGROUND: Cardiac magnetic resonance (CMR) is increasingly used for the diagnosis and management of cardiac diseases. Recent studies have reported immediate post-CMR DNA double-strand breaks in T lymphocytes. We sought to evaluate CMR-induced DNA damage in lymphocytes, alterations of blood cells, and their temporal persistence. METHODS AND RESULTS: In 20 prospectively enrolled healthy men (31.4+/-7.9 years), blood was drawn before and after (1-2 hours, 2 days, 1 month, and 1 year) unenhanced 1.5T CMR. Blood cell counts, cell death, and activation status of lymphocytes, monocytes, neutrophils, and platelets were evaluated. The first 2-hour post-CMR were characterized by a small increase of lymphocyte B and neutrophil counts and a transient drop of total lymphocytes because of a decrease in natural killer cells. Among blood cells, only neutrophils and monocytes displayed slight and transient activation. DNA double-strand breaks in lymphocytes were quantified through flow cytometric analysis of H2AX phosphorylation (gamma-H2AX). gamma-H2AX intensity in T lymphocytes did not change early after CMR but increased significantly at day 2 </=1 month before returning to baseline levels of 1-year post-CMR. CONCLUSIONS: Unenhanced CMR is associated with minor but significant immediate blood cell alterations or activations figuring inflammatory response, as well as DNA damage in T lymphocytes observed from day 2 until the first month but disappearing at 1-year follow-up. Although further studies are required to definitely state whether CMR can be used safely, our findings already call for caution when it comes to repeat this examination within a month.
http://hdl.handle.net/2268/186924
[fr] http://reflexions.ulg.ac.be/IRMCardiaque
[en] http://reflexions.ulg.ac.be/en/CardiacIRM
(c) 2015 American Heart Association, Inc.

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