[en] Rapid screening of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans using quadrupole ion storage tandem-in-time mass spectrometry (QISTMS) conjointly with polyclonal antibody immunoassay has been considered. The optimisation of the fragmentation of the parent ion in the trap has been completed. The analysis of fly ashes from a municipal waste incinerator contaminated at different levels has then been realised. Results obtained using QISTMS, HRMS and immunoassay are compared.
Disciplines :
Chemistry
Author, co-author :
Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique
Eppe, Gauthier ; Université de Liège - ULiège > Centre interfac. d'analyse des résidus en traces (CART)
De Pauw, Edwin ; Université de Liège - ULiège > Chimie physique, spectrométrie de masse
Language :
English
Title :
Optimisation and Use of Tandem-in-Time Mass Spectrometry in Comparison with Immunoassay and Hrgc/Hrms for Pcdd/F Screening
Bosveld A.T.C., Vanden Berg M. (1994) Biomarkers and bioassays as alternative screening methods for the presence and effects of PCDD, PCDF and PCB. Fresenius J. Anal. Chem. 348:106-110.
Bovee T.F.H., Hoogenboom L.A.P., Hamers A.R.M., Traag W.A., Zuidema T., Aarts J.M.J.G., Brouwer A., Kuiper H.A. (1998) Validation and use of the CALUX-bioassay for the determination of dioxins and PCBs in bovine milk. Food Addit. Contam. 15:863-875.
Cairns T., Fishbein L., Mitchum R.K. (1980) Review of the dioxin problem. Mass spectrometric analyses of tetrachlorodioxins in environmental samples. Biomed. Mass Spectrom. 7:484-492.
Chess E.K., Gross M.L. (1980) Determination of tetrachlorodibenzo-p-dioxins by mass spectrometric metastable decomposition monitoring. Anal. Chem. 52:2057-2061.
Garrison P.M., Tullis K., Aarts J.M.J.G., Brouwer A., Giesy J.P., Denison M.S. (1996) Species-specific recombinant cell lines as bioassay systems for the detection of 2,3,7,8-tetrachlorodibenzo-p-dioxin-like chemicals. Fundam. Appl. Toxicol. 30:194-203.
Harrison R.O., Carlson R.E. (1997) A new dioxin/furan immunoassay with low picogram sensitivity and specificity appropriate for TEQ measurement. Organohalogen Compd. 31:139-144.
Harrison R.O., Carlson R.E. (1997) An immunoassay for TEQ screening of dioxin/furan samples: Current status of assay and applications development. Chemosphere 34:915-928.
Harrison R.O., Carlson R.E. (1998) Measurement of PCDD/F TEQ by immunoassay: Demonstration using real world samples. Organohalogen Compd. 35:43-46.
Hayward D.G., Hooper K., Andrzejewski D. (1999) Tandem-in-time mass spectrometry method for the sub-parts-per-trillion determination of 2,3,7,8-chlorine-substituted dibenzo-p-dioxins and furans in high-fat foods. Anal. Chem. 71:212-220.
March R.E. (1991) A musing on the present state of the ion trap and prospects for future applications. Org. Mass Spectrom. 26:627-632.
Mukerjee D. (1998) Health impact of polychlorinated dibenzo-p-dioxins: A critical review. J. Air and Waste Manage. Assoc. 48:157-165.
Plomley J.B., Koester J., March R.E. (1994) Rapid screening technique for tetrachlorodibenzo-p-dioxins in complex environmental matrices by gas chromatography/tandem mass spectrometry with an ion trap detector. Org. Mass Spectrom. 29:372-381.
Plomley J.F., March R.E. (1996) Tandem mass spectrometry of polychlorodibenzo-p-dioxin and polychlorodibenzofuran in a quadrupole ion trap. 1. Comparison of single frequency, secular frequency modulation, and multifrequency resonant excitation modes. Anal. Chem. 68:2345-2352.
Safe S.H. (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26:371-399.
Schwirzer S.M.G., Hofmaier A.M., Kettrup A., Nerdinger P.E., Schramm K.-W., Thoma H., Wegenke M., Wiebel F.J. (1998) Establishment of a simple cleanup procedure and bioasssay for determining 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalents of environmental samples. Ecotoxicol. Environ. Saf. 41:77-82.
Splendore M., Plomley J.B., March R.E., Mercer R.S. (1997) Tandem mass spectrometric determination of polychlorinated dibenzo-p-dioxins and polychlorodibenzofurans in a quadrupole ion trap using multifrequency resonant excitation. Int. J. Mass Spectrom. Ion Processes 165-166:595-609.
Sugawara Y., Gee S.J., Sanborn J.R., Gilman S.D., Hammock B.D. (1998) Development of a highly sensitive enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of polychlorinated dibenzo-p-dioxins. Anal. Chem. 70:1092-1099.
Tyler C.R., Jobling S., Sumpter J.P. (1998) Endocrine disruption in wildlife: A critical review of evidence. Crit. Rev. Toxicol. 28:319-361.
Windal I., Eppe G., Gridelet A.-C., Pauw E. (1998) Supercritical fluid extraction of polychlorinated dibenzo-p-dioxins from fly ash: The importance of the fly ash origin and composition on extraction efficiency. J. Chromatogr. A 819:187-195.
Zennegg M., Harrison R.O., Schmid P. (1998) Application of a PCDD/PCDF immunoassay for the determination of TEQ in fly ash - A comparison with GC/MS data. Organohalogen Compd. 35:213-215.
