[en] In this study, preparation and evaluation of liposomes, intended for intravenous administration, encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes were realized. An increase in Ro solubility, via formation of binary (Ro/HP beta CD) or ternary (Ro/HP beta CD/L-lysine) complexes, permitted a similar increase in encapsulation efficiency of liposomes (Table 1). Moreover, Ro release kinetics depend on the encapsulation efficiency.
Disciplines :
Chemistry Pharmacy, pharmacology & toxicology
Author, co-author :
Piette, Marie ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Castagne, Delphine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Language :
English
Title :
Preparation and evaluation of liposomes encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes
Publication date :
April 2007
Audience :
International
Journal title :
Journal of Inclusion Phenomena and Macrocyclic Chemistry
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Bibliography
Grams, F., et al: Pyrimidine-2,4,6-Triones: a new effective and selective class of matrix metalloproteinase inhibitors. Biol. Chem. 382, 1277-1285 (2001)
Lein, M., et al: The new synthetic matrix metalloproteinase inhibitor (Roche 28-2653) reduces tumor growth and prolongs survival in a prostate cancer standard rat model. Oncogene 21, 2089-2096 (2002)
Maquoi, E., et al: Anti-invasive, antitumoral, and antiangiogenic efficacy of a pyrimidine-2,4,6-trione derivative, an orally active and selective matrix metalloproteinases inhibitor. Clin. Cancer Res. 10, 4038-4047 (2004)
Bertholet, P., et al: The effect of cyclodextrins on the aqueous solubility of a new MMP inhibitor: phase solubility, 1H-NMR spectroscopy and molecular modeling studies, preparation and stability study of nebulizable solutions. J. Pharm. Pharm. Sci. 8, 164-175 (2005)
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