Abstract :
[en] In this study, preparation and evaluation of liposomes, intended for intravenous administration, encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes were realized. An increase in Ro solubility, via formation of binary (Ro/HP beta CD) or ternary (Ro/HP beta CD/L-lysine) complexes, permitted a similar increase in encapsulation efficiency of liposomes (Table 1). Moreover, Ro release kinetics depend on the encapsulation efficiency.
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