Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators

[en] In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.

Research Center/Unit :

Department of AgroBioChem, University of Liege, 5030, Gembloux, Belgium

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology
Immunology & infectious disease

Author, co-author :

Hamaïdia, Malik ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Staumont, Bernard ; Université de Liège > GIGA-R : Epigénétique Cellulaire et Moléculaire

Duysinx, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie

Louis, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie

Willems, Luc ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Language :

English

Title :

Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators

Alternative titles :

[en] Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators

Publication date :

2016

Journal title :

Current Topics in Medicinal Chemistry

ISSN :

1568-0266

eISSN :

1873-4294

Publisher :

Bentham Science Publishers Ltd., San Francisco, United States - California

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://benthamscience.com/journals/current-topics-in-medicinal-chemistry/article/134323/
http://www.ncbi.nlm.nih.gov/pubmed/26303419

Available on ORBi :

since 29 September 2015

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