Article (Scientific journals)
Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik; Staumont, Bernard; Duysinx, Bernard et al.
2016In Current Topics in Medicinal Chemistry, 16 (7)
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Keywords :
Cancer; epigenetic inhibitors; histone deacetylase; immunotherapy; malignant pleural mesothelioma
Abstract :
[en] In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators.
Research center :
Department of AgroBioChem, University of Liege, 5030, Gembloux, Belgium
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Immunology & infectious disease
Author, co-author :
Hamaïdia, Malik  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Staumont, Bernard ;  Université de Liège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Duysinx, Bernard ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Louis, Renaud ;  Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Willems, Luc  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.
Language :
English
Title :
Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Alternative titles :
[en] Improvement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Publication date :
2016
Journal title :
Current Topics in Medicinal Chemistry
ISSN :
1568-0266
eISSN :
1873-4294
Publisher :
Bentham Science Publishers Ltd., San Francisco, United States - California
Volume :
16
Issue :
7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 September 2015

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