[en] Objectives To evaluate imaging changes occurring in a rat model of elastase-induced abdominal aortic aneurysm (AAA), with emphasis on the intraluminal thrombus (ILT) occurrence.
Methods The post-induction growth of the AAA diameter was characterized using ultrasound in 22 rats. ILT was reported on 13 rats that underwent 14 magnetic resonance imaging (MRI) 2-18 days post-surgery, and on 10 rats that underwent 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/microcomputed tomography examinations 2-27 days post-surgery. Logistic regressions were used to establish the evolution with time of AAA length, diameter, ILT thickness, volume, stratification, MRI and FDG PET signalling properties, and histological assessment of inflammatory infiltrates.
Results All of the following significantly increased with time post-induction (p < 0.001): AAA length, AAA diameter, ILT maximal thickness, ILT volume, ILT iron content and related MRI signalling changes, quantitative uptake on FDG PET, and the magnitude of inflammatory infiltrates on histology. However, the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusion.
Conclusion Our model emphasizes that occurrence of ILT precedes AAA peak growth. Aneurysm growth is associated with increasing levels of iron, signalling properties changes in
both MRI and FDG PET, relating to its biological activities.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège Giga-cardiovascular diseases
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
NCHIMI LONGANG, Alain ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Courtois, Audrey ; Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
EL HACHEMI, Mounia ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Touat, Ziad
Drion, Pierre ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim.
WITHOFS, Nadia ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de médecine nucléaire et imagerie onco
Warnock, Geoff
Bahri, Mohamed Ali ; Université de Liège > Centre de recherches du cyclotron
Dogné, Jean-Michel
CHERAMY-BIEN, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > Service de Chirurgie cardio-vasculaire et thoracique
SCHOYSMAN, Laurent ; Centre Hospitalier Universitaire de Liège - CHU > Service médical de radiodiagnostic
Joskin, Julien
Michel, Jean-Baptiste
Defraigne, Jean-Olivier ; Université de Liège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Plenevaux, Alain ; Université de Liège > Centre de recherches du cyclotron
SAKALIHASAN, Natzi ; Centre Hospitalier Universitaire de Liège - CHU > Service de Chirurgie cardio-vasculaire et thoracique
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