Investigation of the interaction between a β-cyclodextrin and DMPC liposomes: a small angle neutron scattering study

Joset, Arnaud; Grammenos, Angeliki; Hoebeke, Maryse; Leyh, Bernard

doi:10.1007/s10847-015-0558-z

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Investigation of the interaction between a β-cyclodextrin and DMPC liposomes: a small angle neutron scattering study

Joset, Arnaud; Grammenos, Angeliki; Hoebeke, Maryse et al.

2015 • In Journal of Inclusion Phenomena and Macrocyclic Chemistry, 83 (3), p. 227-238

Peer reviewed

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https://hdl.handle.net/2268/185802

DOI
10.1007/s10847-015-0558-z

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Keywords :

small angle neutron scattering (SANS); membrane; cyclodextrin

Abstract :

[en] The Small Angle Neutron Scattering technique (SANS) has been applied to investigate the interaction between a cyclodextrin (CD) and liposomes. From the modelling of the experimental neutron scattering cross sections, the detailed structure of dimyristoylphosphatidylcholine (DMPC) liposomes is assessed upon addition of increasing amounts of randomly methylated β-CD (RAMEB). This study has been performed at two temperatures bracketing the phase transition of the DMPC bilayers. The fraction of DMPC molecules incorporated into the vesicles is inferred. The dose-dependent phospholipidic extraction by RAMEB is quantified as well as the concomitant evolution of the liposome radius and of the thickness of the hydrophobic and hydrophilic parts of the membrane. The possible formation of CD-DMPC inclusion complexes is also assessed. The data suggest the dose-dependent coverage by RAMEB of the outer liposome interface. Our analysis highlights the important role of temperature on the mechanism of action of RAMEB. These results are discussed in the framework of the Area-Difference-Elasticity model.

Research center :

Molecular Dynamics Laboratory

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Joset, Arnaud ; University of Liège (ULg), Department of Chemistry, Molecular Dynamics Laboratory

Grammenos, Angeliki; University of Liège (ULg), Department of Physics, Laboratory of Biomedical Spectroscopy

Hoebeke, Maryse ; University of Liège (ULg), Department of Physics, Laboratory of Biomedical Spectroscopy

Leyh, Bernard ; University of Liège (ULg), Department of Chemistry, Molecular Dynamics Laboratory

Language :

English

Title :

Investigation of the interaction between a β-cyclodextrin and DMPC liposomes: a small angle neutron scattering study

Publication date :

2015

Journal title :

Journal of Inclusion Phenomena and Macrocyclic Chemistry

ISSN :

1388-3127

eISSN :

1573-1111

Publisher :

Springer

Volume :

Issue :

Pages :

227-238

Peer reviewed :

Peer reviewed

Funders :

the NMI3 network funded by the European Commission

Available on ORBi :

since 10 September 2015

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