Article (Scientific journals)
In Vitro Comparison of the Antimycotic Activity of a Miconazole-Hp-Beta-Cyclodextrin Solution with a Miconazole Surfactant Solution
Piel, Géraldine; Hayette, Marie-Pierre; Pavoni, Ermanno et al.
2001In Journal of Antimicrobial Chemotherapy, 48 (1), p. 83-7
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Abstract :
[en] The antimycotic activity of a new parenteral solution containing miconazole was compared with that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the Belgian market, probably because of toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing miconazole (10 mg/mL) (like the marketed solution), in combination with hydroxypropyl-beta-cyclodextrin and lactic acid. The MICs of these two solutions were determined by a broth microdilution method (based on NCCLS guidelines) for 67 yeasts and 50 filamentous fungi isolates. This study shows that the MICs obtained with these two solutions are not significantly different.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Piel, Géraldine  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Hayette, Marie-Pierre  ;  Université de Liège - ULiège > Microbiologie médicale
Pavoni, Ermanno
Evrard, Brigitte  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Van Hees, Thierry ;  Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique
Henry de Hassonville, Sandrine
De Mol, Patrick ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale
Delattre, Luc ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
In Vitro Comparison of the Antimycotic Activity of a Miconazole-Hp-Beta-Cyclodextrin Solution with a Miconazole Surfactant Solution
Publication date :
July 2001
Journal title :
Journal of Antimicrobial Chemotherapy
ISSN :
0305-7453
eISSN :
1460-2091
Publisher :
Oxford University Press, United Kingdom
Volume :
48
Issue :
1
Pages :
83-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 August 2009

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